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首页> 外文期刊>Physics in medicine and biology. >Reference tissue modeling with parameter coupling: application to a study of SERT binding in HIV.
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Reference tissue modeling with parameter coupling: application to a study of SERT binding in HIV.

机译：具有参数耦合的参考组织建模：应用于研究HIV中的SERT结合。

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When applicable, it is generally preferred to evaluate positron emission tomography (PET) studies using a reference tissue-based approach as that avoids the need for invasive arterial blood sampling. However, most reference tissue methods have been shown to have a bias that is dependent on the level of tracer binding, and the variability of parameter estimates may be substantially affected by noise level. In a study of serotonin transporter (SERT) binding in HIV dementia, it was determined that applying parameter coupling to the simplified reference tissue model (SRTM) reduced the variability of parameter estimates and yielded the strongest between-group significant differences in SERT binding. The use of parameter coupling makes the application of SRTM more consistent with conventional blood input models and reduces the total number of fitted parameters, thus should yield more robust parameter estimates. Here, we provide a detailed evaluation of the application of parameter constraint and parameter coupling to [(11)C]DASB PET studies. Five quantitative methods, including three methods that constrain the reference tissue clearance (k(r)(2)) to a common value across regions were applied to the clinical and simulated data to compare measurement of the tracer binding potential (BP(ND)). Compared with standard SRTM, either coupling of k(r)(2) across regions or constraining k(r)(2) to a first-pass estimate improved the sensitivity of SRTM to measuring a significant difference in BP(ND) between patients and controls. Parameter coupling was particularly effective in reducing the variance of parameter estimates, which was less than 50% of the variance obtained with standard SRTM. A linear approach was also improved when constraining k(r)(2) to a first-pass estimate, although the SRTM-based methods yielded stronger significant differences when applied to the clinical study. This work shows that parameter coupling reduces the variance of parameter estimates and may better discriminate between-group differences in specific binding.
机译：如果适用，通常最好使用基于参考组织的方法来评估正电子发射断层扫描（PET）研究，因为它避免了需要进行侵入性动脉血液采样的情况。但是，大多数参考组织方法已显示出依赖于示踪剂结合水平的偏差，并且参数估计值的可变性可能会受到噪声水平的很大影响。在一项对HIV痴呆患者血清素转运蛋白（SERT）结合的研究中，确定将参数耦合应用于简化的参考组织模型（SRTM）可减少参数估计的可变性，并在SERT结合方面产生最强的组间显着性差异。参数耦合的使用使SRTM的应用与常规血液输入模型更加一致，并减少了拟合参数的总数，因此应产生更可靠的参数估计。在这里，我们提供了参数约束和参数耦合在[（11）C] DASB PET研究中的应用的详细评估。五种定量方法，包括将参考组织清除率（k（r）（2））约束为跨区域通用值的三种方法，已应用于临床和模拟数据，以比较示踪剂结合电位（BP（ND））的测量。与标准SRTM相比，跨区域的k（r）（2）耦合或将k（r）（2）约束到首过估计可以提高SRTM测量患者和患者之间BP（ND）显着差异的敏感性。控件。参数耦合在减少参数估计值的方差方面特别有效，该方差小于标准SRTM获得的方差的50％。当将k（r）（2）约束为首过估计时，线性方法也得到了改善，尽管基于SRTM的方法在临床研究中产生了更明显的差异。这项工作表明参数耦合减小了参数估计的方差，并且可以更好地区分特定绑定中的组间差异。

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