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首页> 外文期刊>Physics in medicine and biology. >Quantification of iron in the presence of calcium with dual-energy computed tomography (DECT) in an ex vivo porcine plaque model.
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Quantification of iron in the presence of calcium with dual-energy computed tomography (DECT) in an ex vivo porcine plaque model.

机译：在离体猪斑块模型中用双能计算机断层扫描（DECT）对钙存在下的铁进行定量。

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Iron deposits secondary to microbleeds often co-exist with calcium in coronary plaques. The purpose of this study was to quantify iron in the presence of calcium in an ex vivo porcine arterial plaque model using a clinical dual-energy CT (DECT) scanner. A material decomposition method to quantify the mass fractions of iron and calcium within a mixture using DECT was developed. Mixture solutions of known iron and calcium concentrations were prepared to calibrate and validate the DECT-based algorithm. Simulated plaques with co-existing iron and calcium were created by injecting the mixture solutions into the vessel wall of porcine carotid arteries and aortas. These vessel regions were harvested and scanned using a clinical DECT system and iron mass fraction was calculated for each sample. Iron- and calcium-specific staining was conducted on 5 microm thick histological sections of vessel samples to confirm the co-existence of iron and calcium in the simulated plaques. The proposed algorithm accurately quantified iron and calcium amounts in mixture solutions. Maps of iron mass fraction of 60 artery segments were obtained from CT images at two energies. The sensitivity for detecting the presence of iron was 83% and the specificity was 92% using a threshold at an iron mass fraction of 0.25%. Histological analysis confirmed the co-localization of iron and calcium within the simulated plaques. Iron quantification in the presence of calcium was feasible in excised arteries at an iron mass fraction of around 1.5% or higher using current clinical DECT scanners.
机译：继发于微血的铁沉积物通常与冠状动脉斑块中的钙共存。这项研究的目的是使用临床双能CT（DECT）扫描仪对离体猪动脉斑块模型中钙存在下的铁进行定量。开发了一种使用DECT定量分析混合物中铁和钙的质量分数的材料分解方法。准备了已知铁和钙浓度的混合溶液，以校准和验证基于DECT的算法。通过将混合物溶液注入猪颈动脉和主动脉的血管壁中，可以生成具有铁和钙共存的模拟噬菌斑。使用临床DECT系统收集并扫描这些血管区域，并计算每个样品的铁质量分数。对血管样品的5微米厚的组织切片进行铁和钙特异性染色，以确认模拟斑块中铁和钙的共存。所提出的算法可准确定量混合溶液中的铁和钙含量。从两个能量的CT图像获得了60个动脉节段的铁质分数图。使用铁质量分数为0.25％的阈值，检测铁的存在的灵敏度为83％，特异性为92％。组织学分析证实了模拟斑块中铁和钙的共定位。使用当前的临床DECT扫描仪，在钙离子存在的情况下，在切除的动脉中以1.5％或更高的铁质量分数进行铁定量是可行的。

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