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首页> 外文期刊>Physics in medicine and biology. >The feasibility of MRI-guided whole prostate ablation with a linear aperiodic intracavitary ultrasound phased array.
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The feasibility of MRI-guided whole prostate ablation with a linear aperiodic intracavitary ultrasound phased array.

机译：线性非周期性腔内超声相控阵成像在MRI指导下进行全前列腺消融的可行性。

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Over the past decade, numerous minimally invasive thermal procedures have been investigated to treat benign prostate hyperplasia and prostate cancer. Of these methods, ultrasound has shown considerable promise due to its ability to produce more precise and deeper thermal foci. In this study, a linear, transrectal ultrasound phased array capable of ablating large tissue volumes was fabricated and evaluated. The device was designed to be compatible for use with MRI guidance and thermometry. The intracavitary applicator increases treatable tissue volume by using an ultrasonic motor to provide a mechanical rotation angle of up to 100 degrees to a 62-element 1D ultrasound array. An aperiodic array geometry was used to reduce grating lobes. In addition, a specially designed Kapton interconnect was used to reduce cable crosstalk and hence also improve the acoustic efficiency of the array. MRI-guided in vivo and ex vivo experiments were performed to verify the array's large-volume ablative capabilities. Ex vivo bovine experiments were performed to assess the focusing range of the applicator. The array generated foci in a 3 cm (2 to 5 cm from the array surface along the axis normal to the array) by 5.5 cm (along the long axis of the array) by 6 cm (along the transverse axis of the array at a depth of 4 cm) volume. In vivo rabbit thigh experiments were performed to evaluate the lesion producing capabilities in perfused tissue. The array generated 3 cm x 2 cm x 2 cm lesions with 8 to 12 half-minute sonications equally spaced in the volume. The results indicate that transrectal ultrasound coagulation of the whole prostate is feasible with the developed device.
机译：在过去的十年中，已经研究了许多微创热疗法来治疗良性前列腺增生和前列腺癌。在这些方法中，由于其产生更精确和更深的热灶的能力，超声已显示出可观的前景。在这项研究中，制造并评估了能够消融大组织体积的线性，经直肠超声相控阵。该设备设计为与MRI引导和测温法兼容。腔内施用器通过使用超声马达为62个元素的1D超声阵列提供高达100度的机械旋转角来增加可治疗的组织体积。非周期性阵列几何形状用于减少光栅波瓣。此外，还使用了特别设计的Kapton互连来减少电缆串扰，从而也提高了阵列的声学效率。进行了MRI指导的体内和离体实验，以验证阵列的大量消融能力。进行离体牛实验以评估涂药器的聚焦范围。阵列在3厘米（沿与阵列垂直的轴的距离，距离阵列表面2至5厘米），5.5厘米（沿阵列的长轴），6厘米（沿阵列的横轴）处生成焦点深度4厘米）的体积。进行体内兔大腿实验以评估在灌注组织中的病变产生能力。阵列产生3厘米x 2厘米x 2厘米的病变，并在体积中等间隔分布8至12个半分钟的超声。结果表明，经开发的装置可以对整个前列腺进行经直肠超声凝固。

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