• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Limitations of quantitative photoacoustic measurements of blood oxygenation in small vessels
【24h】

Limitations of quantitative photoacoustic measurements of blood oxygenation in small vessels

机译：小血管中血液氧合定量光声测量的局限性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We investigate the feasibility of obtaining accurate quantitative information, such as local blood oxygenation level (sO(2)), with a spatial resolution of about 50 mu m from spectral photoacoustic(PA) measurements. The optical wavelength dependence of the peak values of the PA signals is utilized to obtain the local blood oxygenation level. In our in vitro experimental models, the PA signal amplitude is found to be linearly proportional to the blood optical absorption coefficient when using ultrasonic transducers with central frequencies high enough such that the ultrasonic wavelengths are shorter than the light penetration depth into the blood vessels. For an optical wavelength in the 578-596 nm region, with a transducer central frequency that is above 25 MHz, the sensitivity and accuracy of sO(2) inversion is shown to be better than 4%. The effect of the transducer focal position on the accuracy of quantifying blood oxygenation is found to be negligible. In vivo oxygenation measurements of rat skin microvasculature yield results consistent with those from in vitro studies, although factors specific to in vivo measurements, such as the spectral dependence of tissue optical attenuation, dramatically affect the accuracy of sO(2) quantification in vivo.
机译：我们调查从频谱光声（PA）测量中获取空间分辨率约为50微米的准确定量信息（如局部血液氧合水平（sO（2）））的可行性。 PA信号的峰值的光波长依赖性用于获得局部血液氧合水平。在我们的体外实验模型中，发现使用中心频率足够高的超声换能器时，PA信号幅度与血液光吸收系数成线性比例，从而使超声波长短于光穿透血管的深度。对于578-596 nm范围内的光波长，换能器中心频率高于25 MHz，显示sO（2）反演的灵敏度和精度优于4％。发现换能器焦点位置对定量血液氧合的准确性的影响可以忽略。大鼠皮肤微脉管系统的体内氧化测量结果与体外研究一致，尽管特定于体内测量的因素（例如组织光学衰减的光谱依赖性）极大地影响了sO（2）体内定量的准确性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号