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首页> 外文期刊>Physics in medicine and biology. >Nondestructive measurement of esophageal biaxial mechanical properties utilizing sonometry
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Nondestructive measurement of esophageal biaxial mechanical properties utilizing sonometry

机译：超声法对食管双轴力学性能的无损测量

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Malignant esophageal pathology typically requires resection of the esophagus and reconstruction to restore foregut continuity. Reconstruction options are limited and morbid. The esophagus represents a useful target for tissue engineering strategies based on relative simplicity in comparison to other organs. The ideal tissue engineered conduit would have sufficient and ideally matched mechanical tolerances to native esophageal tissue. Current methods for mechanical testing of esophageal tissues both in vivo and ex vivo are typically destructive, alter tissue conformation, ignore anisotropy, or are not able to be performed in fluid media. The aim of this study was to investigate biomechanical properties of swine esophageal tissues through nondestructive testing utilizing sonometry ex vivo. This method allows for biomechanical determination of tissue properties, particularly longitudinal and circumferential moduli and strain energy functions. The relative contribution of mucosal-submucosal layers and muscular layers are compared to composite esophagi. Swine thoracic esophageal tissues (n = 15) were tested by pressure loading using a continuous pressure pump system to generate stress. Preconditioning of tissue was performed by pressure loading with the pump system and pre-straining the tissue to in vivo length before data was recorded. Sonometry using piezocrystals was utilized to determine longitudinal and circumferential strain on five composite esophagi. Similarly, five mucosa-submucosal and five muscular layers from thoracic esophagi were tested independently. This work on esophageal tissues is consistent with reported uniaxial and biaxial mechanical testing and reported results using strain energy theory and also provides high resolution displacements, preserves native architectural structure and allows assessment of biomechanical properties in fluid media. This method may be of use to characterize mechanical properties of tissue engineered esophageal constructs.
机译：食道恶性病理通常需要切除食道并进行重建以恢复前肠的连续性。重建的选择是有限且病态的。食道代表了与其他器官相比相对简单的组织工程策略的有用目标。理想的组织工程导管将具有对天然食道组织的足够且理想地匹配的机械公差。用于体内和离体的食道组织机械测试的当前方法通常是破坏性的，改变组织构象，忽略各向异性或不能在流体介质中进行。这项研究的目的是通过离体超声测定法通过无损检测研究猪食管组织的生物力学特性。该方法允许生物力学确定组织特性，特别是纵向和圆周模量和应变能函数。将粘膜下粘膜下层和肌肉层的相对贡献与复合食管进行比较。猪胸段食管组织（n = 15）通过使用连续压力泵系统产生压力的压力加载进行测试。通过用泵系统加载压力并在记录数据之前将组织预拉伸到体内长度来进行组织的预处理。使用压电晶体的超声测量法用于确定五个复合食管的纵向和圆周应变。同样，分别测试了来自胸膜食管的五个粘膜下粘膜下层和五个肌肉层。在食道组织上的这项工作与报道的单轴和双轴力学测试以及使用应变能理论的报道结果相一致，并且还提供了高分辨率位移，保留了原始建筑结构并允许评估流体介质中的生物力学特性。该方法可用于表征组织工程化食道构造的机械性能。

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