...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Proton energy optimization and reduction for intensity-modulated proton therapy
【24h】

Proton energy optimization and reduction for intensity-modulated proton therapy

机译：质子能量优化和强度调制质子治疗的降低

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intensity-modulated proton therapy (IMPT) is commonly delivered via the spotscanning technique. To 'scan' the target volume, the proton beam is controlled by varying its energy to penetrate the patient's body at different depths. Although scanning the proton beamlets or spots with the same energy can be as fast as 10-20 m s-1, changing from one proton energy to another requires approximately two additional seconds. The total IMPT delivery time thus depends mainly on the number of proton energies used in a treatment. Current treatment planning systems typically use all proton energies that are required for the proton beam to penetrate in a range from the distal edge to the proximal edge of the target. The optimal selection of proton energies has not been well studied. In this study, we sought to determine the feasibility of optimizing and reducing the number of proton energies in IMPT planning. We proposed an iterative mixed-integer programming optimization method to select a subset of all available proton energies while satisfying dosimetric criteria. We applied our proposed method to six patient datasets: four cases of prostate cancer, one case of lung cancer, and one case of mesothelioma. The numbers of energies were reduced by 14.3%-18.9% for the prostate cancer cases, 11.0% for the lung cancer cases and 26.5% for the mesothelioma case. The results indicate that the number of proton energies used in conventionally designed IMPT plans can be reduced without degrading dosimetric performance. The IMPT delivery efficiency could be improved by energy layer optimization leading to increased throughput for a busy proton center in which a delivery system with slow energy switch is employed.
机译：调强质子治疗（IMPT）通常通过点胶技术进行。为了“扫描”目标体积，可通过改变质子束的能量以在不同深度穿透患者的身体来控制质子束。尽管以相同的能量扫描质子子束或斑点可能快至10-20 m s-1，但从一种质子能量转换为另一种质子能量大约需要另外两秒钟。因此，总的IMPT递送时间主要取决于治疗中使用的质子能量的数量。当前的治疗计划系统通常使用质子束在从靶的远侧边缘到近侧边缘的范围内穿透所需的所有质子能量。质子能量的最佳选择尚未得到很好的研究。在这项研究中，我们试图确定在IMPT规划中优化和减少质子能量数量的可行性。我们提出了一种迭代混合整数规划优化方法，以在满足剂量标准的同时选择所有可用质子能量的子集。我们将提出的方法应用于六个患者数据集：四例前列腺癌，一例肺癌和一例间皮瘤。前列腺癌病例的能量减少了14.3％-18.9％，肺癌病例减少了11.0％，间皮瘤病例减少了26.5％。结果表明，在不降低剂量学性能的情况下，可以减少常规设计的IMPT计划中使用的质子能量数量。通过能量层优化可以提高IMPT的输送效率，从而提高繁忙的质子中心的通量，在繁忙的质子中心中，采用具有缓慢能量转换的输送系统。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号