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首页> 外文期刊>Physics in medicine and biology. >Mapping human skeletal muscle perforator vessels using a quantum well infrared photodetector (QWIP) might explain the variability of NIRS and LDF measurements
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Mapping human skeletal muscle perforator vessels using a quantum well infrared photodetector (QWIP) might explain the variability of NIRS and LDF measurements

机译：使用量子阱红外光电探测器（QWIP）绘制人体骨骼肌穿支血管的地图可能解释了NIRS和LDF测量的可变性

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摘要

Near-infrared spectroscopy (NIRS) and laser Doppler flowmetry (LDF) have become the techniques of choice allowing the non-invasive study of local human skeletal muscle metabolism and blood perfusion on a small tissue volume (a few cm3). However, it has been shown that both NIRS and LDF measurements may show a large spatial variability depending on the position of the optodes over the investigated muscle. This variability may be due to local morphologic and/or metabolic characteristics of the muscle and makes the data interpretation and comparison difficult. In the present work, we use a third method to investigate this problem which permits fast, non-invasive mapping of the intramuscular vessel distribution in the human vastus lateralis muscle. This method uses an advanced, passive, infrared imaging sensor called a QWIP (quantum well infrared photodetector). We demonstrate, using a recovery-enhanced infrared imaging technique, that there is a significant presence of perforator vessels in the region of interest of ～30 * 18 cm (the number of vessels being: 14, 9, 8, 33, 17 and 18 for each subject, respectively). The presence of these vessels makes the skeletal muscle highly inhomogeneous, and may explain the observed NIRS and LDF spatial variability. We conclude that accurate comparison of the metabolic activity of two different muscle regions is not possible without reliable maps of vascular 'singularities' such as the perforator vessels, and that the QWIP-based imaging system is one method to obtain this information.
机译：近红外光谱（NIRS）和激光多普勒血流仪（LDF）已成为选择的技术，可用于在小组织体积（几cm3）上进行非侵入性的局部人骨骼肌代谢和血液灌注研究。但是，已经显示，NIRS和LDF测量值都可能显示较大的空间变异性，具体取决于视点在被研究肌肉上的位置。这种可变性可能是由于肌肉的局部形态和/或代谢特征造成的，并且使得数据解释和比较困难。在当前的工作中，我们使用第三种方法来研究此问题，该问题允许快速，无创地绘制人侧股外侧肌中肌内血管分布。这种方法使用一种称为QWIP（量子阱红外光电探测器）的先进的被动式红外成像传感器。我们使用增强的红外成像技术证明，在〜30 * 18 cm的目标区域中存在明显的穿支血管（血管数量为：14、9、8、33、17和18分别针对每个主题）。这些血管的存在使骨骼肌高度不均匀，并且可以解释观察到的NIRS和LDF空间变异性。我们得出的结论是，如果没有可靠的血管“奇异点”（例如穿支脉管）图，不可能对两个不同肌肉区域的代谢活性进行准确比较，而基于QWIP的成像系统是获取此信息的一种方法。

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