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首页> 外文期刊>Physics in medicine and biology. >Photothermal coagulation of blood vessels: a comparison of high-speed optical coherence tomography and numerical modelling.
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Photothermal coagulation of blood vessels: a comparison of high-speed optical coherence tomography and numerical modelling.

机译：血管的光热凝结：高速光学相干断层扫描和数值建模的比较。

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摘要

Optical-thermal models that can accurately predict temperature rise and damage in blood vessels and surrounding tissue may be used to improve the treatment of vascular disorders. Verification of these models has been hampered by the lack of time- and depth-resolved experimental data. In this preliminary study, an optical coherence tomography system operating at 4-30 frames per second was used to visualize laser irradiation of cutaneous (hamster dorsal skin flap) blood vessels. An argon laser was utilized with the following parameters: pulse duration 0.1-2.0 s, spot size 0.1-1.0 mm, power 100-400 mW. Video microscopy images were obtained before and after irradiations, and optical-thermal modelling was performed on two irradiation cases. Time-resolved optical coherence tomography and still images were compared with predictions of temperature rise and damage using Monte Carlo and finite difference techniques. In general, predicted damage agreed with the actual blood vessel and surrounding tissue coagulation seen in images. However, limitations of current optical-thermal models were identified, such as the inability to model the dynamic changes in blood vessel diameter that were seen in the optical coherence tomography images.
机译：可以准确预测血管和周围组织的温度升高和损伤的光学热模型可用于改善血管疾病的治疗。这些模型的验证因缺乏时间和深度解析的实验数据而受阻。在这项初步研究中，以每秒4-30帧的速度运行的光学相干断层扫描系统可对皮肤（仓鼠背部皮肤皮瓣）血管的激光照射进行可视化。使用具有以下参数的氩激光：脉冲持续时间0.1-2.0 s，光斑尺寸0.1-1.0 mm，功率100-400 mW。在照射前后获得视频显微镜图像，并对两个照射情况进行光热建模。使用蒙特卡罗和有限差分技术，将时间分辨的光学相干断层扫描和静态图像与温度升高和损坏的预测进行了比较。通常，预测的损伤与图像中看到的实际血管和周围组织的凝结相吻合。但是，目前的光学热模型存在局限性，例如无法对光学相干断层扫描图像中看到的血管直径动态变化建模。

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