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首页> 外文期刊>Physics in medicine and biology. >Estimation of cerebral oxy- and deoxy-haemoglobin concentration changes in a layered adult head model using near-infrared spectroscopy and multivariate statistical analysis.
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Estimation of cerebral oxy- and deoxy-haemoglobin concentration changes in a layered adult head model using near-infrared spectroscopy and multivariate statistical analysis.

机译：使用近红外光谱法和多元统计分析估算成年成年头部模型中脑中氧合和脱氧血红蛋白浓度的变化。

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摘要

The non-invasive measurement of cerebral oxy- (DeltaHbO(br)2) and deoxy-haemoglobin (DeltaHHb(br)) changes using near-infrared spectroscopy instruments is often affected by the absorption in the extracerebral layer. We have exploited the multivariate calibration (partial least squares, PLS) method to minimize the errors for a range of blood volume, oxygen saturation and extracerebral layer thicknesses. The changes in the mean time of flight of photons (Delta tau) and attenuation (DeltaA) on the surface of a 3D adult head model were simulated using a finite-element method based on the diffusion equation. The PLS was then performed to identify the optimal number of detectors, their positions and weightings, to optimize the estimation of DeltaHbO(br)2 and DeltaHHb(br). We define the 'nominal accuracy' as the accuracy of estimating DeltaHbO(br)2 and DeltaHHb(br) over a nominal range of extracerebral layer thicknesses and 'robustness' as the accuracy beyond the nominal range. The results showed that for oneor two detectors, Delta tau performed better than DeltaA while using them together gave the best performance. When more detectors were used, the performances of using Delta tau, DeltaA or both together became comparable, showing that a larger number of detectors can compensate for the performance of a simple DeltaA measurement despite this measurement having a relatively lower sensitivity to intracerebral absorption changes.
机译：使用近红外光谱仪对脑氧-（DeltaHbO（br）2）和脱氧血红蛋白（DeltaHHb（br））变化的无创测量通常会受到脑外层吸收的影响。我们已经利用多元校正（偏最小二乘，PLS）方法来最小化一系列血容量，血氧饱和度和脑外层厚度的误差。使用基于扩散方程的有限元方法，模拟了3D成人头部模型表面上光子的平均飞行时间（Delta tau）和衰减（DeltaA）的变化。然后执行PLS来确定探测器的最佳数量，其位置和权重，以优化DeltaHbO（br）2和DeltaHHb（br）的估计。我们将“标称精度”定义为在大脑外层厚度标称范围内估算DeltaHbO（br）2和DeltaHHb（br）的精度，而“稳健性”则定义为超出标称范围的精度。结果表明，对于一个或两个探测器，Delta tau的性能要优于DeltaA，而同时使用它们可以提供最佳性能。当使用更多的检测器时，使用Delta tau，DeltaA或两者一起使用时的性能变得可比，这表明尽管该检测器对脑内吸收变化的敏感性相对较低，但更多的检测器可以补偿简单DeltaA测量的性能。

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