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首页> 外文期刊>Physics in medicine and biology. >Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation.
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Predicted risks of second malignant neoplasm incidence and mortality due to secondary neutrons in a girl and boy receiving proton craniospinal irradiation.

机译：接受质子颅脊髓照射的女孩和男孩中次生中子引起的第二恶性肿瘤发生率和死亡率的预测风险。

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The purpose of this study was to compare the predicted risks of second malignant neoplasm (SMN) incidence and mortality from secondary neutrons for a 9-year-old girl and a 10-year-old boy who received proton craniospinal irradiation (CSI). SMN incidence and mortality from neutrons were predicted from equivalent doses to radiosensitive organs for cranial, spinal and intracranial boost fields. Therapeutic proton absorbed dose and equivalent dose from neutrons were calculated using Monte Carlo simulations. Risks of SMN incidence and mortality in most organs and tissues were predicted by applying risks models from the National Research Council of the National Academies to the equivalent dose from neutrons; for non-melanoma skin cancer, risk models from the International Commission on Radiological Protection were applied. The lifetime absolute risks of SMN incidence due to neutrons were 14.8% and 8.5%, for the girl and boy, respectively. The risks of a fatal SMN were 5.3% and 3.4% for the girl and boy, respectively. The girl had a greater risk for any SMN except colon and liver cancers, indicating that the girl's higher risks were not attributable solely to greater susceptibility to breast cancer. Lung cancer predominated the risk of SMN mortality for both patients. This study suggests that the risks of SMN incidence and mortality from neutrons may be greater for girls than for boys treated with proton CSI.
机译：这项研究的目的是比较接受质子颅骨脊髓照射（CSI）的9岁女孩和10岁男孩的次级恶性肿瘤（SMN）发生率和继发中子死亡率的预测风险。可以从与颅，脊柱和颅内增强场等辐射敏感器官相同的剂量预测中子引起的SMN发生率和死亡率。使用蒙特卡罗模拟计算质子的治疗性质子吸收剂量和等效剂量。通过将国家科学院国家研究委员会的风险模型应用于中子的等效剂量，可以预测大多数器官和组织中SMN发生和死亡的风险。对于非黑色素瘤皮肤癌，采用了国际放射防护委员会的风险模型。女孩和男孩的中子导致的SMN发生的终生绝对风险分别为14.8％和8.5％。女孩和男孩的致命SMN风险分别为5.3％和3.4％。该女孩除结肠癌和肝癌外，罹患任何SMN的风险均较高，这表明该女孩的较高风险并非仅归因于对乳腺癌的更大易感性。肺癌占两名患者SMN死亡的风险最高。这项研究表明，女孩接受中子使SMN发生和死亡的风险可能比接受质子CSI的男孩更大。

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