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首页> 外文期刊>Physics in medicine and biology. >Optimizing wavelength choice for quantitative optoacoustic imaging using the Cramer-Rao lower bound.
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Optimizing wavelength choice for quantitative optoacoustic imaging using the Cramer-Rao lower bound.

机译：使用Cramer-Rao下限为定量光声成像优化波长选择。

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摘要

Several papers have recently addressed the issue of estimating chromophore concentration in optoacoustic imaging (OAI) using multiple wavelengths. The choice of wavelengths obviously affects the accuracy and precision of the estimates. One might assume that the wavelengths that maximize the extinction coefficients of the chromophores would be the most suitable. However, this may not always be the case since the distribution of light intensity in the medium is also wavelength dependent. In this paper, we explore a method for optimizing the choice of wavelengths based on the Cramer-Rao lower bound (CRLB) on the variance of the chromophore concentration. This lower bound on variance can be evaluated numerically for different wavelengths using the variation of the extinction coefficients and scattering coefficients with wavelength. The wavelengths that give the smallest variance will be considered optimal for multi-wavelength OAI to estimate the chromophore concentrations. The expression for the CRLB has been derived analytically for estimating the concentration of multiple chromophores for several simple phantom models for the case when the optoacoustic signal is proportional to the product of the optical absorption and the illumination function. This approach could be easily extended to other geometries.
机译：最近有几篇论文讨论了使用多种波长估计光声成像（OAI）中发色团浓度的问题。波长的选择显然会影响估计的准确性和准确性。可以假定使发色团的消光系数最大化的波长将是最合适的。但是，由于介质中光强度的分布也与波长有关，因此并非总是如此。在本文中，我们探索了一种基于发色团浓度方差的Cramer-Rao下限（CRLB）优化波长选择的方法。可以使用消光系数和散射系数随波长的变化，针对不同的波长，通过数值方式评估方差的下限。对于多波长OAI估计生色团浓度，给出最小方差的波长将被认为是最佳的。 CRLB的表达式已通过分析得出，用于在光声信号与光吸收与照明函数的乘积成比例的情况下，针对几种简单的幻像模型来估计多个发色团的浓度。这种方法可以很容易地扩展到其他几何形状。

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