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首页> 外文期刊>Biomaterials >Self-assembled biomimetic monolayers using phospholipid-containing disulfides.
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Self-assembled biomimetic monolayers using phospholipid-containing disulfides.

机译：使用含磷脂的二硫化物的自组装仿生单层。

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摘要

Several phospholipid-based disulfide molecules were synthesized and attached onto the gold-coated silicon wafer using the self-assembling method. The syntheses of these surface-modifying agents were conducted by introducing bromoethylphosphorate (PBr), phosphorylcholine (PC) or phosphorylethanolamine (PE) groups on the terminals of a dialkyl disulfide. After disulfides adsorption onto gold substrate surfaces, the composition, the film thickness, and the conformational order of self-assembled monolayer surfaces were explored and discussed in detail based on reflection-absorption infrared spectroscopy, contact angle measurement, Auger electron spectroscopy, X-ray photoelectron spectroscopy, and so on. The monolayer having the PBr end group could also be converted to a PC surface by treating with trimethylamine. The model functional surfaces of Au-SC11-PC, -PE, -PBr, -OH or corresponding mixed layers were used to mimic biomembrane surfaces. The monolayer having PC groups was found to reduce fibrinogen adsorption as evaluated from protein adsorption experiments using quartz crystal microbalance. It also showed relatively low platelet adherence compare to the glass, PBr and PE surfaces. The cell viability test also revealed that the PC surface displayed lower cytotoxicity than other surfaces.
机译：合成了几个基于磷脂的二硫化物分子，并使用自组装方法将其附着到镀金的硅片上。这些表面改性剂的合成是通过在二烷基二硫化物的末端引入溴代乙基溴代磷酸酯（PBr），磷酰胆碱（PC）或磷酰乙醇胺（PE）基团来进行的。二硫化物吸附到金基底表面后，基于反射吸收红外光谱，接触角测量，俄歇电子能谱，X射线，探讨并讨论了自组装单层表面的组成，膜厚和构象顺序。光电子能谱等。具有PBr端基的单层也可以通过用三甲胺处理而转化为PC表面。使用Au-SC11-PC，-PE，-PBr，-OH或相应的混合层的模型功能表面来模拟生物膜表面。如使用石英晶体微量天平的蛋白质吸附实验所评估，发现具有PC基团的单层减少了纤维蛋白原的吸附。与玻璃，PBr和PE表面相比，它还显示出相对较低的血小板粘附性。细胞活力测试还显示，PC表面显示出比其他表面更低的细胞毒性。

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