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首页> 外文期刊>Biomaterials >Hemocompatibility and anaphylatoxin formation of protein-immobilizing polyacrylonitrile hemodialysis membrane.
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Hemocompatibility and anaphylatoxin formation of protein-immobilizing polyacrylonitrile hemodialysis membrane.

机译：固定蛋白的聚丙烯腈血液透析膜的血液相容性和过敏毒素形成。

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摘要

Plasma proteins were covalently immobilized onto polyacrylonitrile (PAN) membrane to evaluate the hemocompatibility and anaphylatoxin formation. This is used as a model to study the effect of protein-adsorption on the blood-contacting response of hemodializing membranes. The proteins used were either platelet-adhesion-promoting collagen (COL) or platelet-adhesion-inhibiting human serum albumin (HSA). The microstructure and characterization of the protein-immobilizing PAN membranes were evaluated by Coomassie dye assay, atomic force microscopy, X-ray photoelectron spectroscopy and water contact angle measurement. PAN-HSA membrane improved not only hemocompatibility including less platelet adhesion, longer blood coagulation times, and higher thrombin inactivity level, but also induced lower complement activation. On the other hand, PAN-COL membrane exhibited blood incompatibility, although induced less increase of C3, C4 antigens of serum. Overall results of this study demonstrated that the immobilization of HSA onto the surface of PAN membrane would be beneficial to improve the hemocompatibility and to reduce the anaphylatoxin formation during hemodialysis.
机译：将血浆蛋白共价固定在聚丙烯腈（PAN）膜上，以评估血液相容性和过敏毒素的形成。该模型用作研究蛋白质吸附对血液透析膜血液接触反应影响的模型。所使用的蛋白质是促进血小板粘附的胶原蛋白（COL）或抑制血小板粘附的人血清白蛋白（HSA）。通过考马斯亮色分析，原子力显微镜，X射线光电子能谱和水接触角测量来评估固定蛋白质的PAN膜的微观结构和表征。 PAN-HSA膜不仅改善了血液相容性，包括更少的血小板粘附，更长的凝血时间和更高的凝血酶失活水平，而且还诱导了较低的补体激活。另一方面，尽管PAN-COL膜引起的血清C3，C4抗原的增加较少，但显示出血液不相容性。这项研究的总体结果表明，将HSA固定在PAN膜表面上将有利于改善血液相容性并减少血液透析过程中过敏毒素的形成。

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