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首页> 外文期刊>Biomaterials >Electrospinning of nano/micro scale poly(l-lactic acid) aligned fibers and their potential in neural tissue engineering.
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Electrospinning of nano/micro scale poly(l-lactic acid) aligned fibers and their potential in neural tissue engineering.

机译：纳米/微米级聚（l-乳酸）排列纤维的电纺及其在神经组织工程中的潜力。

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摘要

Efficacy of aligned poly(l-lactic acid) (PLLA) nano/micro fibrous scaffolds for neural tissue engineering is described and their performance with random PLLA scaffolds is compared as well in this study. Perfectly aligned PLLA fibrous scaffolds were fabricated by an electrospinning technique under optimum condition and the diameter of the electrospun fibers can easily be tailored by adjusting the concentration of polymer solution. As the structure of PLLA scaffold was intended for neural tissue engineering, its suitability was evaluated in vitro using neural stem cells (NSCs) as a model cell line. Cell morphology, differentiation and neurite outgrowth were studied by various microscopic techniques. The results show that the direction of NSC elongation and its neurite outgrowth is parallel to the direction of PLLA fibers for aligned scaffolds. No significant changes were observed on the cell orientation with respect to the fiber diameters. However, the rate of NSC differentiation was higher for PLLA nanofibers than that of micro fibers and it was independent of the fiber alignment. Based on the experimental results, the aligned nanofibrous PLLA scaffold could be used as a potential cell carrier in neural tissue engineering.
机译：描述了对齐的聚（l-乳酸）（PLLA）纳米/微纤维支架对神经组织工程的功效，并在本研究中还比较了它们与随机PLLA支架的性能。通过静电纺丝技术在最佳条件下制造出完美排列的PLLA纤维支架，通过调节聚合物溶液的浓度可以轻松地定制静电纺丝的直径。由于PLLA支架的结构旨在用于神经组织工程，因此使用神经干细胞（NSC）作为模型细胞系在体外评估其适用性。通过各种显微技术研究了细胞形态，分化和神经突生长。结果表明，NSC伸长的方向和其神经突的长出方向与对齐支架的PLLA纤维的方向平行。相对于纤维直径，未观察到细胞取向的显着变化。然而，PLLA纳米纤维的NSC分化速率高于微纤维，并且与纤维排列无关。基于实验结果，对齐的纳米纤维PLLA支架可用作神经组织工程中潜在的细胞载体。

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