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首页> 外文期刊>Biomaterials >Synthesis of creatinine-imprinted poly(beta-cyclodextrin) for the specific binding of creatinine.
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Synthesis of creatinine-imprinted poly(beta-cyclodextrin) for the specific binding of creatinine.

机译：肌酐印迹聚（β-环糊精）的肌酐特异性结合的合成。

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An artificial receptor for creatinine was synthesized by the method of molecularly imprinted polymer (MIP). beta-Cyclodextrin was used as a monomer cross-linked with epichlorohydrin in the presence of creatinine, which was a template for the imprinting. Different molar ratios of monomer to template were used to synthesize the polymers so that better specific adsorption ability towards creatinine could be achieved. The results showed that to carry out the polymerization with a molar ratio of monomer to template of 3:2 and monomer to cross-linking agent of 1:10 was proper. N-hydroxysuccinimide and 2-pyrrolinidone were used as the analogues of creatinine in the adsorption experiments of multi-component solutions to reveal the specific recognition ability of the molecularly imprinted poly(beta-cyclodextrin) (poly(beta-CD)) for the template molecule, creatinine. One such detection interference of creatinine was creatine, which also co-exists in serum. Hence, adsorption experiments of creatinine/creatine binary mixture were also carried out to investigate and confirm the specific binding of the creatinine-imprinted poly(beta-cyclodextrin) towards creatinine. The hydroxyl groups of the imprinted poly(beta-CD) was further capped by chlorotrimethylsilane (CTMS) to investigate the interaction between creatinine and the imprinted poly(beta-CD). The adsorption resulting from the mixture solution by MIPs suggested that the creatinine-imprinted poly(beta-CD) demonstrated superior binding effect for the target molecule, creatinine, rather than creatine, N-hydroxysuccinimide and 2-pyrrolinidone.
机译：通过分子印迹聚合物（MIP）的方法合成了肌酐的人工受体。在存在肌酐的情况下，β-环糊精用作与环氧氯丙烷交联的单体，肌酐是印记的模板。使用单体与模板的不同摩尔比来合成聚合物，从而可以实现对肌酸酐的更好的比吸附能力。结果表明，以单体与模板的摩尔比为3：2和单体与交联剂的摩尔比为1:10进行聚合是合适的。在多组分溶液的吸附实验中，N-羟基琥珀酰亚胺和2-吡咯烷酮被用作肌酸酐的类似物，以揭示分子印迹聚β-环糊精（poly-CD）对模板的特异性识别能力。分子肌酐。肌酸酐的一种这样的检测干扰是肌酸，肌酸也共存于血清中。因此，还进行了肌酐/肌酸二元混合物的吸附实验，以研究并证实肌酐印迹聚（β-环糊精）对肌酐的特异性结合。印记的聚（β-CD）的羟基被氯三甲基硅烷（CTMS）进一步封端，以研究肌酐与印记的聚（β-CD）之间的相互作用。 MIPs从混合溶液中产生的吸附表明，肌酐印迹的聚β-CD对目标分子肌酐而非肌酸，N-羟基琥珀酰亚胺和2-吡咯烷酮具有优异的结合作用。

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