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首页> 外文期刊>Biomaterials >STERILIZATION, TOXICITY, BIOCOMPATIBILITY AND CLINICAL APPLICATIONS OF POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMERS
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STERILIZATION, TOXICITY, BIOCOMPATIBILITY AND CLINICAL APPLICATIONS OF POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMERS

机译：聚乳酸多羟基乙酸共聚物的灭菌，毒性，生物相容性及临床应用

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This is a review of salient studies of sterilization, toxicity, biocompatibility, clinical applications and current work in the field of orthopaedics, using implants made of polylactic acid (PLA), polyglycolic acid (PGA) and their copolymers. The intrinsic nature of these biomaterials renders them suitable for applications where temporally slow releases of bioactive agents in situ may be required. They are also desirable as fixation devices of bone, because they can virtually eliminate osteopenia associated with stress shielding or additional surgery. The majority of currently available sterilization techniques are not suitable for these thermoplastic materials and it may be desirable to develop new sterilization standards, which can account for the special character of PLA-PGA materials. Biocompatibility and toxicity studies suggest that, overall, PLA-PGA biomaterials may be suitable for orthopaedic applications, although certain problems, especially pertaining to reduction in cell proliferation, have been reported. Clinical applications are also promising, albeit not without problems usually associated with transient tissue inflammation. The future of these materials appears bright, especially in soft tissues. They may be used to address the exceedingly complex problem of osteochondral repair, but also as a means to enhance fixation and repair processes in tendons and ligaments. [References: 100]
机译：这是对使用聚乳酸（PLA），聚乙醇酸（PGA）及其共聚物制成的植入物进行的灭菌，毒性，生物相容性，临床应用和骨科领域当前工作的重要研究的综述。这些生物材料的固有性质使其适合于可能需要在时间上缓慢释放生物活性剂的应用。它们还理想地用作骨的固定装置，因为它们实际上可以消除与应力屏蔽或其他手术有关的骨质减少。当前大多数可用的灭菌技术均不适用于这些热塑性材料，因此可能需要开发新的灭菌标准，以说明PLA-PGA材料的特殊特性。生物相容性和毒性研究表明，尽管已经报道了某些问题，尤其是与细胞增殖减少有关的问题，但总的来说，PLA-PGA生物材料可能适用于整形外科。尽管并非没有通常与短暂组织发炎有关的问题，但临床应用也很有希望。这些材料的未来似乎是光明的，尤其是在软组织中。它们可以用于解决骨软骨修复的极其复杂的问题，也可以用作增强腱和韧带的固定和修复过程的手段。 [参考：100]

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