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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats.
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The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats.

机译：雌激素对顺铂诱导的大鼠肾毒性过程中某些代谢酶活性的影响。

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摘要

Cisplatin is one of the widely used chemothrapeutic agents. One of the major side effects of the drug is renal toxicity. The aims of the presented study was (1) to investigate the effect of cisplatin on some renal metabolic enzyme activities such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH), and malate dehydrogenase (MDH) in an experimental model of acute renal failure and (2) to examine the protective role of erdosteine, an expectorant agent which has also antioxidant properties on cisplatin-induced nephrotoxicity and the enzyme activities mentioned above. Female Wistar albino rats were divided into three groups: sham operation group ( [Formula: see text] ), cisplatin group ( [Formula: see text] ), [Formula: see text] group ( [Formula: see text] ). All the chemicals used were applied intraperitoneally. Hexokinase, G6PD, LDH, and MDH activities were determined in the kidney supernatant at the end of the surgical procedures. Spectrophotometric methods were used to determine the activities of above-mentioned enzymes in the kidney tissue. Hexokinase and G6PD activities were found to be increased in cisplatin group compared to control group. G6PD activities were found to be decreased in [Formula: see text] group compared to cisplatin group. There were minimal changes in LDH and MDH activities of the two study groups compared with the control group. The results obtained suggested that the glucose metabolizing metabolic pathways of renal tissue were partially affected from cisplatin toxicity and erdosteine have some protective effects on these enzyme activities.
机译：顺铂是广泛使用的化学治疗剂之一。该药物的主要副作用之一是肾脏毒性。本研究的目的是（1）研究顺铂对某些肾脏代谢酶活性的影响，例如己糖激酶（HK），葡萄糖6磷酸脱氢酶（G6PD），乳酸脱氢酶（LDH）和苹果酸脱氢酶（MDH）。 ）在急性肾功能衰竭的实验模型中，以及（2）研究了祛痰剂Erdosteine的保护作用，该祛痰剂对顺铂诱导的肾毒性和上述酶活性也具有抗氧化作用。将雌性Wistar白化病大鼠分成三组：假手术组（[公式：参见正文]），顺铂组（[公式：参见正文]），[公式：参见正文]组（[公式：参见正文]）。所用的所有化学药品均经腹膜内施用。在外科手术结束时，在肾脏上清液中测定了己糖激酶，G6PD，LDH和MDH活性。使用分光光度法确定肾脏组织中上述酶的活性。与对照组相比，顺铂组的己糖激酶和G6PD活性增加。与顺铂组相比，[配方：见正文]组发现G6PD活性降低。与对照组相比，两个研究组的LDH和MDH活性变化很小。所得结果表明，肾脏组织的葡萄糖代谢代谢途径受到顺铂毒性的部分影响，而鄂尔多斯汀对这些酶的活性具有一定的保护作用。

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