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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Paroxetine alters KCl- or ATP-induced contractile responses of isolated vas deferens in rats chronically treated with ethanol.
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Paroxetine alters KCl- or ATP-induced contractile responses of isolated vas deferens in rats chronically treated with ethanol.

机译：帕罗西汀改变用乙醇长期治疗的大鼠中分离的输精管的KCl或ATP诱导的收缩反应。

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摘要

Chronic ethanol administration affects many organ systems, including sexual organs. One of these organs is the vas deferens whose contractility can also be altered by selective serotonin re-uptake inhibitors (SSRIs). The aim of the present study, is to evaluate whether paroxetine (PX), a SSRI, can modify the contractile responses of isolated vas deferens obtained from rats chronically treated with ethanol to the contractile agents, potassium chloride (KCl) and adenosine triphosphate (ATP). For 21 days, alcohol was applied with a modified liquid diet to sexually mature male Sprague-Dawley rats (200-240g). The vas deferens of the rats were excised at the end of day 21 and suspended in the organ baths by classical pharmacological methods. The responses to contractile agents tested were decreased by chronic ethanol treatment in all groups compared to their untreated matches. PX (10(-7) and 10(-6)M) potentiated the contractions to KCl (20-180mM) and ATP (10(-6) to 10(-3)M) in epididymal portion but its higher concentrations (10(-5) and 10(-4)M) inhibited the responses, both in the control and chronically ethanol treated rat groups. Prazosin (PR), an alpha adrenergic receptor blocker, could not inhibit PX-induced potentiation in lower concentrations of KCl but could inhibit the potentiation occurred at higher concentrations of KCl in epididymal portion both in the control and chronically ethanol treated rat groups. PR also inhibited PX-induced potentiation on the responses to ATP in epididymal portion both in the control and chronically ethanol treated rat groups. In conclusion, all the results obtained in this study, suggest that chronic ethanol treatment decreased the contractility of vas deferens but did not alter the action pattern of PX on responses to KCl and ATP in rat vas deferens. On the other hand, the potentiation of responses to contractile agents induced by PX can be partially considered as the result of inhibition of noradrenaline re-uptake.
机译：长期服用乙醇会影响许多器官系统，包括性器官。这些器官之一是输精管，其收缩力也可通过选择性5-羟色胺再摄取抑制剂（SSRI）改变。本研究的目的是评估帕罗西汀（PX）（SSRI）是否可以改变用乙醇长期治疗的大鼠分离的输精管对收缩剂，氯化钾（KCl）和三磷酸腺苷（ATP）的收缩反应。 ）。在21天中，将酒精和改良的流质饮食应用于性成熟的雄性Sprague-Dawley大鼠（200-240g）。在第21天结束时切除大鼠的输精管，并通过经典药理学方法将其悬浮在器官浴中。与未治疗的比赛相比，所有组中通过长期乙醇治疗对测试的收缩剂的反应均降低。 PX（10（-7）和10（-6）M）会增强附睾部分收缩至KCl（20-180mM）和ATP（10（-6）至10（-3）M），但其浓度较高（10 （-5）和10（-4）M）在对照组和长期用乙醇处理的大鼠组中均抑制了反应。鼠肾上腺素受体阻滞剂Prazosin（PR）在较低浓度的KCl中不能抑制PX诱导的增强作用，但在对照组和慢性乙醇治疗的大鼠组的附睾部位，抑制较高浓度的KCl时发生的增强作用。在对照组和长期用乙醇处理的大鼠组中，PR还抑制了附睾部分对PX诱导的对ATP反应的增强作用。总之，本研究获得的所有结果表明，慢性乙醇治疗降低了输精管的收缩性，但并未改变PX对大鼠输精管中KCl和ATP的反应的作用方式。另一方面，由于抑制了去甲肾上腺素的再摄取，PX诱导的对收缩剂应答的增强可以部分地考虑。

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