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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >In utero exposure to tobacco and alcohol modifies neurobehavioral development in mice offspring: consideration a role of oxidative stress.
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In utero exposure to tobacco and alcohol modifies neurobehavioral development in mice offspring: consideration a role of oxidative stress.

机译：在子宫内暴露于烟草和酒精会改变小鼠后代的神经行为发育：应考虑氧化​​应激的作用。

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OBJECTIVE: To determine whether in utero tobacco and alcohol exposure induces long-term neurobehavioral alterations and whether oxidative stress/damage is a possible causal factor. METHODS: Gravid mice were subjected to tobacco smoking and alcohol consumption. Their offspring were subsequently evaluated in developmental and behavioral tests. Antioxidative enzymes and erythrocyte membrane fluidity of adult offspring were measured. RESULTS: The intrauterine tobacco and alcohol exposure has resulted in significant reduced postnatal body and organ weights accompanied by reduced gestational body weight gain in their mothers. Such exposure also induced remarkable developmental delay in neonatal reflexes and notable behavioral deficit in adulthood, namely reduced motive coordination and locomotor activity as well as impaired learning and memory abilities. Furthermore, the formation of malondialdehyde (MDA) increased significantly whereas the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), catalase (Cat) and glutathione S-transferases (GST) decreased in the cerebral cortex and liver of prenatal intoxicated offspring. The embryonic intoxication also markedly reduced erythrocyte membrane fluidity in offspring. CONCLUSION: Our study shows the long-term neurotoxicity associated with prenatal tobacco and alcohol exposure, and suggests that the deleterious outcome may be in relation to increased free radicals formation and oxidative stress.
机译：目的：确定在子宫内吸烟和饮酒是否会引起长期的神经行为改变，以及氧化应激/损伤是否是可能的原因。方法：对妊娠小鼠进行吸烟和饮酒。他们的后代随后在发育和行为测试中得到评估。测量了成年后代的抗氧化酶和红细胞膜流动性。结果：宫内抽烟和饮酒导致母亲的产后体重和器官重量显着减少，同时孕期的体重增加也有所减少。这种接触还引起新生儿反射的显着发育延迟和成年期明显的行为缺陷，即运动协调​​和运动能力降低以及学习和记忆能力受损。此外，产前大脑皮层和肝脏中丙二醛（MDA）的形成显着增加，而超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GSH-PX），过氧化氢酶（Cat）和谷胱甘肽S-转移酶（GST）的活性降低。陶醉的后代。胚胎中毒还显着降低了后代的红细胞膜流动性。结论：我们的研究显示了与产前吸烟和饮酒有关的长期神经毒性，并表明有害的结局可能与自由基形成增加和氧化应激有关。

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