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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Contractile effect of acetylcholine on isolated ampullar segment of fallopian tubes.
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Contractile effect of acetylcholine on isolated ampullar segment of fallopian tubes.

机译：乙酰胆碱对输卵管孤立壶腹节段的收缩作用。

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The Fallopian tubes are scarcely innervated with cholinergic nerve fibers. Acetylcholine released from these nerves contracts smooth muscles of the tubes. The aim of our study was to investigate the effect of acetylcholine on the Fallopian tubes using selective antagonists in different hormonal settings. We have investigated effects of acetylcholine on isolated ampulla of Fallopian tubes taken from 83 patients during abdominal hysterectomy with adnexectomy. Twenty-eight patients were in follicular, 36 were in luteal phase of menstrual cycle, and 19 patients were in menopause. Selective and non-selective muscarinic and nicotinic receptor blockers were used for investigation of the effects. Acetylcholine (from 1.8 to 658.6microM/l) produced concentration-dependent tonic contraction of ampulla taken from the patients in follicular phase, luteal phase and menopause. The nicotinic receptor blocker mecamylamine (6.5microM/l) and local anesthetic lidocaine (230.8microM/l) did not affect the effect of acetylcholine. While M(1)- and M(2)-selective muscarinic receptor blockers pirenzepine (1.6microM/l) and methoctramine (0.9microM/l) did not show specific effect, atropine (0.01microM/l) and selective M(3)-receptor blocker p-fluoro-hexahydro-sila-difenidol (pFHHSiD, 0.2microM/l) effectively blocked contractions caused by acetylcholine (maximal pA(2) values 9.74 and 7.54, respectively). The affinity of pFHHSiD for muscarinic receptors was highest in the follicular phase. The results of our study suggest existence of functional M(3) muscarinic receptors in ampulla of Fallopian tubes, located on the smooth muscle cells.
机译：输卵管几乎不受胆碱能神经纤维的支配。从这些神经释放的乙酰胆碱使管的平滑肌收缩。我们的研究目的是研究在不同激素环境下使用选择性拮抗剂对乙酰胆碱的作用。我们已经研究了乙酰胆碱对从腹部子宫切除术和附件切除术中取出的83例输卵管隔离壶腹的影响。二十八例处于卵泡期，三十六例处于黄体期的月经周期，十九例处于更年期。选择性和非选择性毒蕈碱和烟碱样受体阻滞剂用于研究其作用。乙酰胆碱（1.8至658.6microM / l）引起卵泡期，黄体期和绝经期患者壶腹的浓度依赖性强直收缩。烟碱受体阻滞剂美卡明胺（6.5microM / l）和局麻利多卡因（230.8microM / l）不影响乙酰胆碱的作用。虽然M（1）-和M（2）-选择性毒蕈碱受体阻滞剂哌仑西平（1.6microM / l）和甲基辛特拉明（0.9microM / l）没有显示出特定的作用，阿托品（0.01microM / l）和选择性M（3） -受体阻滞剂p-氟-六氢-sila-difenidol（pFHHSiD，0.2microM / l）有效阻断由乙酰胆碱引起的收缩（最大pA（2）值分别为9.74和7.54）。 pFHHSiD对毒蕈碱受体的亲和力在卵泡期最高。我们的研究结果表明存在功能性M（3）毒蕈碱受体在输卵管壶腹中，位于平滑肌细胞上。

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