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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Interaction between saquinavir and antimycotic drugs on C. albicans and C. neoformans strains.
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Interaction between saquinavir and antimycotic drugs on C. albicans and C. neoformans strains.

机译：沙奎那韦与抗真菌药物在白色念珠菌和新孢梭菌菌株之间的相互作用。

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摘要

Candidiasis and cryptococcosis are the most common fungal diseases among patients suffering from HIV infection. In the present work we assess whether the combined therapies, proteinase inhibitors and antimycotic drugs, could modify the therapeutic effect of antimycotics. An in vitro study to evaluate the antifungal effect of saquinavir and antimycotic drugs combination on yeast growth was performed. Strains of C. albicans and C. neoformans from HIV-seropositive patients were used. Susceptibility tests of yeasts to amphotericin B, 5-fluorocytosine, miconazole and fluconazole, singly and in combination with saquinavir, were performed in two different media. In the combinations the antimycotic agents and saquinavir were tested at sub-inhibitory concentrations: 0.1-10渭gml(-1) and 12.50渭gml(-1), respectively. The fractionary inhibitory concentration (FIC) index was also calculated. The results show that the interaction between saquinavir and all the antimycotic drugs never resulted in antagonism. Fluconazole acts in more synergistic way, no matter which medium is used. The combined therapy miconazole/saquinavir results in synergism, especially in Sabouraud. The total absence of antagonism and the presence of synergism suggest that a combined therapy could be proposed in the treatment of HIV-seropositive patients to reduce side effects, thanks to the use of lower doses of antimycotic drugs.
机译：念珠菌病和隐球菌病是艾滋病毒感染患者中最常见的真菌疾病。在目前的工作中，我们评估了联合疗法，蛋白酶抑制剂和抗真菌药是否可以改变抗真菌药的治疗效果。进行了一项体外研究，以评估沙奎那韦和抗真菌药物组合对酵母菌生长的抗真菌作用。使用了来自HIV血清阳性患者的白色念珠菌和新福寿梭菌菌株。在两种不同的培养基中单独和与沙奎那韦合用了酵母对两性霉素B，5-氟胞嘧啶，咪康唑和氟康唑的药敏试验。在组合中，分别在亚抑制浓度下分别测试了抗真菌药和沙奎那韦：0.1-10μgml（-1）和12.50μgml（-1）。还计算了部分抑制浓度（FIC）指数。结果表明，沙奎那韦与所有抗真菌药物之间的相互作用从未引起拮抗作用。无论使用哪种介质，氟康唑都以更协同的方式起作用。咪康唑/沙奎那韦的联合治疗可产生协同作用，尤其是在萨布罗地区。完全没有拮抗作用和存在协同作用表明，由于使用了较低剂量的抗真菌药物，可以建议在HIV阳性患者中联合治疗以减少副作用。

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