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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >In vivo growth-inhibition of S180 tumor by mixture of 5-Fu and low molecular lambda-carrageenan from Chondrus ocellatus.
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In vivo growth-inhibition of S180 tumor by mixture of 5-Fu and low molecular lambda-carrageenan from Chondrus ocellatus.

机译：5-氟尿嘧啶球菌和低分子λ-角叉菜胶混合物对S180肿瘤的体内生长抑制作用。

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摘要

Lambda-carrageenan is a sulfated galactan isolated from some red algae and have been reported to have many kinds of biological activities. Chondrus ocellatus is an important economic alga in China and many other parts of the world. The sample was obtained after lambda-carrageenan from the alga was degraded by microwave and its molecular weight is 9.3 kDa. In this study, tumor inhibiting activity of low molecular weight lambda-carrageenan and its mixture with 5-Fu on mice transplanted with S180 tumor was investigated. Weight of immune organ, proliferation ratio of lymphocyte concentration of TNF-alpha and histopathology of spleen and tumor from the transplanted S180 tumor mice were also determined. Results indicated that the degraded lambda-carrageenan could enhance antitumor activity of 5-Fu and improve immunocompetence damaged by 5-Fu.
机译：λ-角叉菜胶是从某些红藻中分离出来的一种硫酸化半乳聚糖，据报道具有多种生物活性。在中国和世界其他地区，八角猪都是一种重要的经济藻类。通过微波降解藻类中的λ-角叉菜胶后获得样品，其分子量为9.3 kDa。在这项研究中，研究了低分子量λ-角叉菜胶及其与5-Fu的混合物对移植有S180肿瘤的小鼠的抑瘤活性。还测定了移植的S180肿瘤小鼠的免疫器官重量，TNF-α淋巴细胞浓度的增殖率以及脾脏和肿瘤的组织病理学。结果表明，降解的λ-角叉菜胶可以增强5-Fu的抗肿瘤活性，并改善5-Fu所致的免疫能力。

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