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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >The beneficial effect of L-cysteine supplementation on DNA oxidation induced by forced training.
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The beneficial effect of L-cysteine supplementation on DNA oxidation induced by forced training.

机译：补充L-半胱氨酸对强迫训练诱导的DNA氧化的有益作用。

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BACKGROUND: Forced training is closely implicated with free radicals production and indication of tissue damage as well as DNA oxidation. AIM: To investigate the effect of L-cysteine (L-cys) supplementation on DNA oxidative damage found in basketball players after forced training. SUBJECTS AND METHODS: Blood was obtained from 10 players pre-game (group A), post-game (group B) and after 1 month L-cys (0.5 g 24 h(-1), orally) supplementation, pre- (group C) and post-training (group D). Total antioxidant status (TAS) and the biomarker of DNA oxidative damage 8-hydroxy-2-deoxyguanosine (8-OHdG) as well as creatine kinase (CK) and lactate dehydrogenase (LDH) were measured with commercial kits. RESULTS: TAS was increased in the groups with L-cys (group C and group D). Post-exercise 8-OHdG levels, CK and LDH were remarkably lower (0.16+/-0.03 ng ml(-1), 115+/-15 U l(-1), 417+/-90 U l(-1), respectively) in group D than those in group B (0.36+/-0.05 ng ml(-1), 286+/-12 U l(-1), 688+/-88U l(-1), p<0.001, respectively). 8-OH dG levels were negatively correlated with TAS(r=-0.718, p<0.01) and positively with CK levels(r=0.590, p<0.01). CONCLUSIONS: L-cys supplementation in basketball players may reduce DNA damage induced by training. The sulfur-containing amino acid may protect muscle cells "death" by increasing TAS and the cellular defense against oxidative stress.
机译：背景：强迫训练与自由基的产生，组织损伤的指示以及DNA氧化密切相关。目的：研究补充L-半胱氨酸（L-cys）对篮球运动员在强迫训练后发现的DNA氧化损伤的影响。受试者和方法：血液是从赛前（A组），赛后​​（B组）以及1个月L-cys（0.5 g 24 h（-1）口服）补充，赛前（组）的10位运动员中获得的C）和后期训练（D组）。用商业试剂盒测量了总抗氧化剂状态（TAS）和DNA氧化损伤的生物标志物8-羟基-2-脱氧鸟苷（8-OHdG）以及肌酸激酶（CK）和乳酸脱氢酶（LDH）。结果：L-cys组（C组和D组）的TAS升高。运动后8-OHdG水平，CK和LDH显着降低（0.16 +/- 0.03 ng ml（-1），115 +/- 15 U l（-1），417 +/- 90 U l（-1） D组分别比B组（0.36 +/- 0.05 ng ml（-1），286 +/- 12 U l（-1），688 +/- 88U l（-1），p <0.001 ， 分别）。 8-OH dG水平与TAS呈负相关（r = -0.718，p <0.01），与CK呈正相关（r = 0.590，p <0.01）。结论：在篮球运动员中补充L-cys可减少训练引起的DNA损伤。含硫氨基酸可通过增加TAS和抵抗氧化应激的细胞防御作用来保护肌肉细胞“死亡”。

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