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首页> 外文期刊>Physical chemistry chemical physics: PCCP >Structure and spatial distribution of the spin-labelled lipopeptide trichogin GA IV in a phospholipid membrane studied by pulsed electron-electron double resonance (PELDOR)
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Structure and spatial distribution of the spin-labelled lipopeptide trichogin GA IV in a phospholipid membrane studied by pulsed electron-electron double resonance (PELDOR)

机译：脉冲电子电子双共振（PELDOR）研究磷脂膜中自旋标记的脂蛋白天花粉蛋白GA IV的结构和空间分布

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The method of pulsed electron - electron double resonance (PELDOR) is exploited to study intra- and intermolecular dipole - dipole interactions between the spin labels of trichogin GA IV analogues. This lipopeptaibol antibiotic was studied in multilamellar membranes of dipalmitoylphosphatidylcholine frozen to 77 K. For mono-labelled trichogin analogues, the molecules are shown not to form aggregates in the lipid membranes studied. For the double-labelled trichogin analogues, a function of the distance distribution between the spin labels has been obtained. We determined that the distribution function has two main maxima located at distances of 1.25 nm and 1.75 nm. The value of 1.25 nm is close to the distance between labels of a alpha-helical structure. On the other hand, a distance of 1.75 nm corresponds to a mixed 3D-structure in which a 3(10)-helix is combined with a more elongated conformation.
机译：脉冲电子-电子双共振（PELDOR）方法被用来研究滴虫GA IV类似物的自旋标记之间的分子内和分子间偶极-偶极相互作用。在冷冻至77 K的二棕榈酰磷脂酰胆碱的多层膜中研究了这种脂肽醇抗生素。对于单标记的trichogin类似物，显示该分子在所研究的脂质膜中未形成聚集体。对于双标记的滴虫蛋白类似物，已经获得了自旋标记之间的距离分布的函数。我们确定分布函数有两个主要最大值，分别位于1.25 nm和1.75 nm的距离处。 1.25 nm的值接近于α螺旋结构的标记之间的距离。另一方面，1.75 nm的距离对应于混合的3D结构，其中3（10）螺旋与更细长的构象结合在一起。

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