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首页> 外文期刊>Biomaterials >Impact of heat on nanocrystalline silver dressings Part I: Chemical and biological properties
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Impact of heat on nanocrystalline silver dressings Part I: Chemical and biological properties

机译：热量对纳米晶银敷料的影响第一部分：化学和生物学特性

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Thermal stability of heat-treated nanocrystalline silver dressings was investigated using chemical techniques and biological assays. Dressings were heat-treated for 24 h at temperatures from 23 to 110 degrees C. Bactericidal efficacy of heat-treated dressings was measured using a log reduction assay, while antibacterial longevity was determined via plate-to-plate transfer corrected zone of inhibition assays. Over the temperature range tested, biological activity dropped from excellent to negligible. Biological longevity results showed that controlled release properties of the dressings were significantly reduced by heat treatments above 75 degrees C. These data illustrate nanocrystalline silver sensitivity to heat. Further, it was clear that dressing efficacy is determined by total available soluble silver, not total silver in the dressing. It was determined that the quantity of soluble silver decreased significantly with increased heat treatment temperatures. These results should be considered in developing new nanocrystalline drug delivery systems. (c) 2005 Elsevier Ltd. All rights reserved.
机译：热处理过的纳米晶银敷料的热稳定性使用化学技术和生物测定法进行了研究。敷料在23到110摄氏度的温度下热处理24小时。热处理的敷料的杀菌效力使用对数减少法进行测定，而抗菌寿命则通过板对板转移校正的抑制区进行测定。在测试的温度范围内，生物活性从优异降至可忽略不计。生物寿命结果表明，敷料在75摄氏度以上的热处理显着降低了其控释性能。这些数据说明了纳米晶银对热的敏感性。此外，很明显，敷料的功效由总的可用可溶性银而不是敷料中的总银决定。可以确定，随着热处理温度的升高，可溶性银的含量显着降低。在开发新的纳米晶体药物递送系统时应考虑这些结果。 （c）2005 Elsevier Ltd.保留所有权利。

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