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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet
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Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet

机译：糖纳米肿瘤学：小巧而甜美的结合带来了新的治疗机会

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Recent efforts toward defining the molecular features of the tumor microenvironment have revealed dramatic changes in the expression of glycan-related genes including glycosyltransferases and glycosidases. These changes affect glycosylation of proteins and lipids not only in cancer cells themselves, but also in cancer associated-stromal, endothelial and immune cells. These glycan alterations including increased frequency of beta 1,6-branched N-glycans and bisecting N-glycans, overexpression of tumor-associated mucins, preferred expression of T, Tn and sialyl-Tn antigen and altered surface sialylation, may contribute to tumor progression by masking or unmasking specific ligands for endogenous lectins, including members of the C-type lectin, siglec and galectin families. Differential expression of glycans or glycan-binding proteins could be capitalized for the identification of novel biomarkers and might provide novel opportunities for therapeutic intervention. This review focuses on the biological relevance of lectin-glycan interactions in the tumor microenvironment (mainly illustrated by the immunosuppressive and pro-angiogenic activities of galectin-1) and the design of functionalized nanoparticles for pharmacological delivery of multimeric glycans, lectins or selective inhibitors of lectin-glycan interactions with antitumor activity. (C) 2016 Elsevier Ltd. All rights reserved.
机译：最近为确定肿瘤微环境的分子特征所做的努力表明，与糖相关的基因（包括糖基转移酶和糖苷酶）的表达发生了巨大变化。这些变化不仅影响癌细胞本身，而且影响癌症相关的基质，内皮细胞和免疫细胞中蛋白质和脂质的糖基化。这些聚糖变化包括β1,6-支化N-聚糖和二等分N-聚糖的频率增加，肿瘤相关粘蛋白的过表达，T，Tn和唾液酸-Tn抗原的优选表达以及表面唾液酸化的改变，可能有助于肿瘤进展通过掩蔽或不掩蔽内源性凝集素的特定配体，包括C型凝集素，siglec和半乳凝素家族的成员。聚糖或聚糖结合蛋白的差异表达可用于鉴定新的生物标志物，并可为治疗干预提供新的机会。这篇综述着眼于肿瘤微环境中凝集素-聚糖相互作用的生物学相关性（主要通过galectin-1的免疫抑制和促血管生成活性来说明）和功能化纳米颗粒的设计，用于药理学上递送多聚聚糖，凝集素或选择性抑制剂。凝集素-聚糖相互作用具有抗肿瘤活性。 （C）2016 Elsevier Ltd.保留所有权利。

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