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Hypothermia as a clinical neuroprotectant

机译:低温治疗作为临床神经保护剂

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摘要

Applying therapeutic hypothermia (TH) for the purposes of neuroprotection, originally termed "hibernation," started nearly 100 years ago. Because TH cooling systems have improved to the point where it is practical and safe for general application, interest in providing such treatment in conditions such as spinal cord injury, traumatic brain injury, stroke, and cardiac arrest has increased. This article reviews the mechanisms by which TH mitigates secondary neurologic injury, the clinical scenarios where TH is being applied, and reviews selected published studies using TH for central nervous system neuroprotection.
机译:将治疗性体温过低(TH)用于神经保护的目的(最初称为“冬眠”)始于近100年前。因为TH冷却系统已经改进到可以通用的实用和安全的地步,所以在诸如脊髓损伤,脑外伤,中风和心脏骤停等情况下提供这种治疗的兴趣增加了。本文回顾了TH减轻继发性神经系统损伤的机制,正在应用TH的临床情况,并回顾了使用TH进行中枢神经系统神经保护的一些已发表的研究。

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