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Applications of the P50 evoked response to the evaluation of cognitive impairments after traumatic brain injury.

机译:P50诱发反应在脑外伤后认知功能障碍评估中的应用。

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摘要

This article reviews the applications of the P50 evoked response to paired auditory stimuli (P50 ERP) in the study and evaluation of cognitive impairments after traumatic brain injury (TBI). The cholinergic hypothesis of cognitive impairment after TBI and the relationship of impaired auditory sensory gating to that hypothesis are presented. The neurobiology of impaired sensory gating, the relationship of that neurobiology to the P50 ERP, and the principles of P50 ERP recording are discussed. Studies of the P50 ERP among patients with persistent cognitive complaints after TBI are reviewed. Finally, possible clinical applications and limitations of the P50 ERP in the study, evaluation, and treatment of patients with cognitive impairments after TBI are offered.
机译:本文回顾了对配对听觉刺激的P50诱发反应(P50 ERP)在研究和评估脑外伤(TBI)后认知功能障碍中的应用。提出了TBI后认知障碍的胆碱能假说以及听觉感觉门控受损与该假说的关系。讨论了感觉门控受损的神经生物学,该神经生物学与P50 ERP的关系以及P50 ERP记录的原理。回顾了TBI后持续认知障碍患者中P50 ERP的研究。最后,提供了P50 ERP在TBI后认知障碍患者的研究,评估和治疗中可能的临床应用和局限性。

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