...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomaterials >Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway
【24h】

Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway

机译：通过甲状腺激素三碘甲腺氨酸激活的PI3K / AKT信号途径的代谢重塑促进细胞多能性的诱导

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Generation of induced pluripotent stem cells (iPSCs) from somatic cells by defined factors is a mechanism-unknown, yet extremely time-consuming process. Inefficient reprogramming leads to prolonged periods of . in vitro iPSC selection, resulting in subtle genetic and epigenetic abnormalities. To facilitate pluripotent reprogramming, we have identified the thyroid hormone triiodothyronine (T3) as an endogenous factor that can enhance reprogramming of human dermal fibroblasts (HDF) and umbilical cord mesenchymal stem cells (UCMSC). This potentiation of iPSC induction is associated with metabolic remodeling activity, including upregulation of key glycolytic genes, an increase in cell proliferation, and the induction of mesenchymal-epithelial transition (MET). We further identify the activation of the PI3K/AKT signal pathway by T3 as an underlying mechanism for the enhanced conversion to cell pluripotency in this model. These studies demonstrate that T3 enhances metabolic remodeling of donor cells in potentiating cell reprogramming.
机译：通过确定的因子从体细胞中产生诱导性多能干细胞（iPSC）是未知的机制，但非常耗时。低效的重新编程会导致长时间的。体外iPSC选择，导致细微的遗传和表观遗传异常。为了促进多能性重编程，我们已经确定甲状腺激素三碘甲状腺素（T3）是一种内源性因子，可以增强人皮肤成纤维细胞（HDF）和脐带间充质干细胞（UCMSC）的重编程。 iPSC诱导的这种增强与代谢重塑活性有关，包括关键糖酵解基因的上调，细胞增殖的增加以及间充质-上皮转化（MET）的诱导。我们进一步确定通过T3激活PI3K / AKT信号通路，作为该模型中增强的向细胞多能性转化的潜在机制。这些研究表明，T3在增强细胞重编程中增强了供体细胞的代谢重塑。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号