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首页> 外文期刊>Physica Scripta: An International Journal for Experimental and Theoretical Physics >Opportunities afforded by the intense nanosecond neutron pulses from a plasma focus source for neutron capture therapy and the preliminary simulation results
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Opportunities afforded by the intense nanosecond neutron pulses from a plasma focus source for neutron capture therapy and the preliminary simulation results

机译：来自等离子体聚焦源的纳秒级强中子脉冲提供的机会用于中子俘获治疗和初步模拟结果

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摘要

The use of short and powerful neutron pulses for boron neutron capture therapy (BNCT) can potentially increase selectivity and reduce the total dose absorbed by the patient. The biological effects of radiation depend on the dose, the dose power and the spatial distribution of the microscopic energy deposition. A dense plasma focus (DPF) device emits very short (in the nanosecond range) and extremely intense pulses of fast neutrons (2.5 or 14MeV neutrons - from D-D or D-T nuclear reactions) and x-rays. Optimal spectra of neutrons formed for use in BNCT must contain an epithermal part to ensure a reasonable penetration depth into tissues at high enough cross-section on boron. So the powerful nanosecond pulses of fast neutrons generated by DPF must be moderated. After this moderation, the pulse duration must be shorter compared with the duration of the reaction with free radicals, that is, ≥1μs. In this work we focus on the development of a detailed simulation of interaction of short-pulse radiation from a DPF with the device's materials and with different types of moderators to estimate the dose power at the cells for this dynamic case. The simulation was carried out by means of the Geant4 toolkit in two main steps: the modeling of the pulsed neutron source device itself; the study of the interaction of fast mono-energetic neutrons with a moderator specific for BNCT.
机译：将短而有力的中子脉冲用于硼中子俘获治疗（BNCT）可能会增加选择性并减少患者吸收的总剂量。辐射的生物学效应取决于剂量，剂量功率和微观能量沉积的空间分布。密集等离子体聚焦（DPF）装置发出非常短的脉冲（在纳秒范围内），并发出非常强烈的快速中子脉冲（2.5或14MeV中子-来自D-D或D-T核反应）和X射线。形成用于BNCT的中子的最佳光谱必须包含一个超热部分，以确保在硼上足够高的横截面上具有合理的穿透深度。因此，必须缓和DPF产生的快速中子的强大纳秒脉冲。经过这种调节后，脉冲持续时间必须比与自由基反应的持续时间短，即≥1μs。在这项工作中，我们专注于开发DPF的短脉冲辐射与设备的材料以及不同类型的调节剂之间相互作用的详细模拟，以评估这种动态情况下细胞的剂量功率。通过Geant4工具包在两个主要步骤中进行了仿真：脉冲中子源设备本身的建模;快速单能中子与BNCT专用慢化剂相互作用的研究。

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