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Estimation of instantaneous venous blood saturation using the photoplethysmograph waveform

机译:使用光电容积描记器波形估算瞬时静脉血饱和度

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Non-invasive estimation of regional venous saturation (SxvO(2)) using a conventional pulse oximeter could provide a means of obtaining clinically relevant information. This study was carried out in order to investigate the hypothesis that SxvO(2) could be estimated by utilising the modulations created by positive pressure ventilation in the photoplethysmograph (PPG) signals. The modulations caused by the mechanical ventilator were extracted from oesophageal PPG signals obtained from 12 patients undergoing cardiothoracic surgery. The signals analysed in this work were acquired in a previous study. For the purpose of this analysis the raw PPG signal was considered to have three major components, ac PPG signal (cardiac related component), a static component or dc PPG signal (created mostly by the absorption of light by surrounding tissue) and the ventilator modulation component. These components were then used to estimate instantaneous arterial blood oxygen saturation (SpO(2)) and SxvO(2) by utilising time-frequency analysis technique of smoothed-pseudo Wigner-Ville distribution (SPWVD). The results showed that there was no significant difference in the traditionally-derived (time-domain) arterial saturation and the instantaneous arterial saturation. However, the instantaneous venous saturation was found to be significantly lower than the estimated time-domain and instantaneous arterial saturation (P = < 0.001, n = 12).
机译:使用常规脉搏血氧饱和度计的非侵入性估计区域静脉饱和度(SxvO(2))可以提供一种获得临床相关信息的方法。进行这项研究是为了研究以下假设:可以通过利用光电容积描记器(PPG)信号中的正压通气产生的调制来估算SxvO(2)。机械呼吸机引起的调制是从12例心胸外科手术患者的食道PPG信号中提取的。这项工作中分析的信号是在以前的研究中获得的。为了进行此分析,原始PPG信号被认为具有三个主要分量,交流PPG信号(与心脏有关的分量),静态分量或直流PPG信号(主要是由周围组织对光的吸收产生的)和呼吸机调制零件。然后,通过利用平滑伪Wigner-Ville分布(SPWVD)的时频分析技术,将这些组件用于估算瞬时动脉血氧饱和度(SpO(2))和SxvO(2)。结果显示,传统来源的(时域)动脉饱和度和瞬时动脉饱和度没有显着差异。但是,发现瞬时静脉饱和度明显低于估计的时域和瞬时动脉饱和度(P = <0.001,n = 12)。

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