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首页> 外文期刊>Physica, A. Statistical mechanics and its applications >PROTEIN ADSORPTION ON TETHERED POLYMER LAYERS - EFFECT OF POLYMER CHAIN ARCHITECTURE AND COMPOSITION
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PROTEIN ADSORPTION ON TETHERED POLYMER LAYERS - EFFECT OF POLYMER CHAIN ARCHITECTURE AND COMPOSITION

机译：蛋白质在高分子聚合物层上的吸附-聚合物链结构和组成的影响。

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The ability of tethered polymer layers to modify the adsorption behavior of simple model proteins is studied using single-chain mean-field theory. Several different polymer molecular structures are considered, It is found that branched polymer chains are much more effective in preventing protein adsorption than linear flexible chains. Diblock copolymers formed by a flexible and a rigid block show similar steric repulsion than fully flexible chains of the same number of monomers. However, the distribution of free ends is very different for the two types of molecules. Polymers with the two ends tethered at surfaces are more efficient than chains with one end on the surface with the same molecular weight to prevent protein adsorption. Mixtures of polymer chains at the surface show an ability to prevent protein adsorption that is different from a linear combination of the pure component polymer layers. The effect of attractive interactions between the protein and the segments of the tethered polymer chains is studied. The effective interaction between the protein and the polymer layer shows an attractive part for proteins that are at the tip of the polymer layer in qualitative agreement with recent experimental observations. [References: 42]
机译：使用单链平均场理论研究了束缚的聚合物层改变简单模型蛋白质吸附行为的能力。考虑了几种不同的聚合物分子结构。发现支链聚合物链在阻止蛋白质吸附方面比线性柔性链更有效。与相同数量单体的完全柔性链相比，由柔性和刚性嵌段形成的二嵌段共聚物显示出相似的空间排斥力。但是，两种分子的自由端分布非常不同。两端拴在表面上的聚合物比一端在表面上具有相同分子量的链更有效，以防止蛋白质吸附。表面上的聚合物链混合物显示出防止蛋白质吸附的能力，这与纯组分聚合物层的线性组合不同。研究了蛋白质与束缚的聚合物链段之间有吸引力的相互作用的影响。蛋白质和聚合物层之间的有效相互作用显示出与最近的实验观察定性一致的，位于聚合物层尖端的蛋白质具有吸引力的部分。 [参考：42]

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