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首页> 外文期刊>Photochemical & photobiological sciences: the official journal of the European Photochemistry Association and the European Society for Photobiology >The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate
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The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate

机译：叶酸对5-氨基乙酰丙酸或5-氨基乙酰丙酸甲酯治疗的小鼠肿瘤和正常皮肤卟啉合成的影响

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摘要

5-Aminolevulinic acid (ALA) or its derivative methyl 5-aminolevulinate (MAL) combined with folic acid was applied in nude mice bearing human colon adenocarcinoma. The aim of the study is to see whether folic acid may increase biosynthesis of porphyrins in tumor tissue after systemic or topical administration of ALA or MAL. The production of porphyrins was determined by spectrofluorometric measurements with an optical fibre probe. It was found that the porphyrin production after i.p injection of 200 mg kg(-1) ALA or MAL was significantly increased by i.p injection of 100 mg kg(-1) folic acid. However, in the case of topically applied 20% ALA, folic acid had no effect. In the case of topically applied 20% MAL, folic acid (i.p or topically applied) reduced the porphyrin synthesis. This might be used for the protection of normal skin against photosensitization. The effects of folic acid were similar in tumors and normal skin. Two mechanisms may explain the results: enhancement of the efficiency of the rate-limiting enzyme porphobilinogen deaminase by folic acid or interference of folic acid with the transport of ALA and MAL to and into the cells synthesizing porphyrins in the tissues. The present data seem to favour the latter mechanism. Folic acid may have a role as an adjuvant in photodynamic therapy with systemically administered ALA and its derivatives.
机译：将5-氨基乙酰丙酸（ALA）或其衍生物5-氨基乙酰丙酸甲酯（MAL）与叶酸联合用于患有人结肠腺癌的裸鼠。该研究的目的是观察在全身或局部施用ALA或MAL后，叶酸是否可增强肿瘤组织中卟啉的生物合成。卟啉的产生通过使用光纤探针的荧光分光光度法测定来确定。发现通过腹膜内注射100 mg kg（-1）叶酸，腹膜内注射200 mg kg（-1）ALA或MAL后卟啉的产生显着增加。但是，在局部使用20％ALA的情况下，叶酸无效。在局部施用20％MAL的情况下，叶酸（腹膜内或局部施用）减少了卟啉的合成。这可用于保护正常皮肤免于光敏性。叶酸在肿瘤和正常皮肤中的作用相似。有两种机理可以解释这一结果：叶酸增强限速酶卟啉胆碱原脱氨酶的效率，或叶酸干扰ALA和MAL进入组织中合成卟啉的细胞的迁移。目前的数据似乎支持后一种机制。叶酸在全身应用ALA及其衍生物的光动力治疗中可能起辅助剂的作用。

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