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首页> 外文期刊>Physiological Research >The influence of folate and antioxidants on homocysteine levels and oxidative stress in patients with hyperlipidemia and hyperhomocysteinemia
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The influence of folate and antioxidants on homocysteine levels and oxidative stress in patients with hyperlipidemia and hyperhomocysteinemia

机译：叶酸和抗氧化剂对高脂血症和高同型半胱氨酸血症患者同型半胱氨酸水平和氧化应激的影响

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The aim of this study was to observe the effect of folate and antioxidants alone on homocysteine levels and oxidative stress markers, and to evaluate whether their co-administration promotes their effects. One hundred patients with hyperhomocysteinemia were randomized into four equal groups, which were then treated with folate, antioxidants or folate plus antioxidants for 2 months; group IV was a control group. Serum homocysteine, folate and oxidative stress markers were measured before the study, at the end of folate and/or antioxidants administration and 3 months later. Folate caused a significant decrease in homocysteine concentration. Antioxidants did not influence homocysteine concentration, but they improved the antioxidative defense (plasma antioxidant capacity and intraerythrocyte glutathione were increased) and partially prevented lipid peroxidation (malondialdehyde level was slightly decreased). Supplementation with folate had a similar effect on intracellular glutathione and plasma malondialdehyde. Simultaneous administration of folate and antioxidants did not show any additive effect with the exception of a slower decrease of folate concentration after its supplementation had been discontinued. Folate may be considered as an effective antioxidant in patients with hyperhomocysteinemia; this can be a result of decreased production of free radicals due to a reduced level of homocysteine. Its antioxidative effect cannot be promoted by co-administration of antioxidants.
机译：这项研究的目的是观察叶酸和抗氧化剂对同型半胱氨酸水平和氧化应激标志物的影响，并评估它们的共同给药是否能促进其作用。将一百名高同型半胱氨酸血症患者随机分为四个相同的组，然后分别用叶酸，抗氧化剂或叶酸加抗氧化剂治疗2个月。第四组为对照组。在研究前，叶酸和/或抗氧化剂给药结束时以及3个月后测量血清高半胱氨酸，叶酸和氧化应激指标。叶酸导致同型半胱氨酸浓度显着降低。抗氧化剂不会影响同型半胱氨酸的浓度，但是它们改善了抗氧化防御能力（​​血浆抗氧化能力和红细胞内谷胱甘肽增加了），部分阻止了脂质过氧化（丙二醛水平略有下降）。叶酸补充对细胞内谷胱甘肽和血浆丙二醛有相似的作用。叶酸和抗氧化剂的同时给药没有显示出任何加和作用，只是在停止补充叶酸后降低了叶酸的浓度。叶酸可能被认为是高同型半胱氨酸血症患者的有效抗氧化剂;这可能是由于同型半胱氨酸水平降低导致自由基产生减少的结果。并用抗氧化剂不能促进其抗氧化作用。

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