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STATISTICS FOR CIRRHOSIS DIAGNOSIS BY GC/MS

机译:GC / MS诊断肝硬化的统计数据

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Gas chromatographic-mass spectrometry (GC/MS) is one of the bestmethods used for measuring drugs in biological fluids. The selected ion monitoring(SIW) mode was used in caffeine test measurements by adding known amounts of~(15)N-theophylline as internal standard. A single dose of 4 mg.kg~(-1)p.o. of caffeinewas followed by blood concentrations measurements at two points, l h and 9 h.Caffeine clearance, measured in patients with cirrhosis and chronic hepatitis, wasreduced and half live time was increased in children with liver disease as comparedwith control. Different statistical methods have been used to study the pharmacokineticdata for cirrhosis diagnosis.
机译:气相色谱质谱法(GC / MS)是用于测量生物液体中药物的最佳方法之一。通过添加已知量的〜(15)N-茶碱作为内标,将选定的离子监测(SIW)模式用于咖啡因测试测量。单剂量4 mg.kg〜(-1)p.o。分别在1 h和9 h的两个时间点进行血药浓度测量。与对照组相比,肝硬化和慢性肝炎患者的咖啡因清除率降低,半衰期延长。已经使用了不同的统计方法来研究肝硬化诊断的药代动力学数据。

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