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Advanced Glycation End-Products and the Progress of Diabetic Vascular Complications

机译：先进的糖基化终产物与糖尿病性血管并发症的进展

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摘要

Epidemiological studies have confirmed that hyperglycemia is the most important factor in the onset and progress of vascular complications, both in Type 1 and 2 diabetes mellitus. The formation of advanced glycation end-products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that accelerated chemical modification of proteins by glucose during hyperglycemia contributes to the pathogenesis of diabetic complications including nephropathy, retinopathy, neuropathy and atherosclerosis. Recent studies have shown that increased formation of serum AGEs exists in diabetic children and adolescents with or without vascular complications. Furthermore, the presence of diabetic complications in children correlates with elevated serum AGEs. The level of serum AGEs could be considered as a marker of later developments of vascular complications in children with Type 1 and 2 diabetes mellitus. The careful metabolic monitoring of young diabetics together with monitoring of serum AGEs can provide useful information about impending AGE-related diabetic complications. It is becoming clear that anti-AGE strategies may play an important role in the treatment of young and older diabetic patients. Several potential drug candidates such as AGE inhibitors have been reported recently.
机译：流行病学研究已证实，高血糖症是1型和2型糖尿病患者血管并发症发生和进展的最重要因素。晚期糖基化终产物（AGEs）的形成与血糖控制相关。 AGE假说提出，高血糖期间葡萄糖加速蛋白质的化学修饰会导致糖尿病并发症的发病机理，包括肾病，视网膜病，神经病和动脉粥样硬化。最近的研究表明，在患有或不患有血管并发症的糖尿病儿童和青少年中，血清AGEs的形成增加。此外，儿童糖尿病并发症的存在与血清AGEs升高有关。血清AGEs水平可被认为是1型和2型糖尿病儿童血管并发症后期发展的标志。对年轻糖尿病患者进行仔细的代谢监测以及对血清AGEs的监测可以提供有关即将发生的AGE相关糖尿病并发症的有用信息。显然，抗衰老策略可能在年轻和老年糖尿病患者的治疗中起重要作用。最近已经报道了几种潜在的候选药物，例如AGE抑制剂。

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