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首页> 外文期刊>Physiological Research >Cough, Expiration and Aspiration Reflexes following Kainic Acid Lesions to the Pontine Respiratory Group in Anesthetized Cats
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Cough, Expiration and Aspiration Reflexes following Kainic Acid Lesions to the Pontine Respiratory Group in Anesthetized Cats

机译：海藻酸损害后麻醉猫的the肌呼吸群的咳嗽，呼气和吸入性反射

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摘要

The importance of neurons in the pontine respiratory group for the generation of cough, expiration, and aspiration reflexes was studied on non-decerebrate spontaneously breathing cats under pentobarbitone anesthesia. The dysfunction of neurons in the pontine respiratory group produced by bilateral microinjection of kainic acid (neurotoxin) regularly abolished the cough reflexes evoked by mechanical stimulation of both the tracheobronchial and the laryngopharyngeal mucous membranes and the expiration reflex mechanically induced from the glottis. The aspiration reflex elicited by similar stimulation of the nasopharyngeal region persisted in 73 % of tests, however, with a reduced intensity compared to the pre-lesion conditions. The pontine respiratory group seems to be an important source of the facilitatory inputs to the brainstem circuitries that mediate cough, expiration, and aspiration reflexes. Our results indicate the significant role of pons in the multilevel organization of brainstem networks in central integration of the aforementioned reflexes.
机译：研究了戊巴比妥麻醉下非去脑自发呼吸猫的脑部呼吸组神经元对于咳嗽，呼气和吸气反射产生的重要性。双边显微注射海藻酸（神经毒素）产生的桥脑呼吸组神经元功能紊乱，通常消除了机械刺激气管支气管和喉咽粘膜引起的咳嗽反射，以及声门机械诱发的呼气反射。由鼻咽区域的类似刺激引起的抽吸反射在73％的测试中持续进行，但与病变前情况相比强度降低。桥脑呼吸群似乎是介导咳嗽，呼气和抽吸反射的脑干回路促进性输入的重要来源。我们的结果表明pons在上述反射的中央整合中在脑干网络的多层组织中起着重要作用。

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