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首页> 外文期刊>Physiological Research >Effects of Anesthesia and Nociceptive Stimulation in an Experimental Model of Brachial Plexus Avulsion
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Effects of Anesthesia and Nociceptive Stimulation in an Experimental Model of Brachial Plexus Avulsion

机译：麻醉和伤害性刺激在臂丛撕脱实验模型中的作用

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Unilateral dorsal rhizotomy of brachial plexus nerves (C5-Th1) performed under general anesthesia is known to induce self-mutilation in rats. The aim of this study was to determine the effect of different anesthetic agents, and of pre-rhizotomy nociceptive stimulation on the appearance of self-mutilation. Self-mutialtion appeared in 78 % of animals after rhizotomy had been performed under pentobarbital anesthesia. When ketamine was used as the general anesthetic, self-mutilation was almost suppressed (13 %) and consisted of superficial erosions. Mechanical nociceptive stimulation, when applied just before the induction of ketamine anesthesia and subsequent rhizotomy, provoked self-mutilation in 91 % of rats. Furthermore, a serious type of self-mutilation consisting of total amputation of the distal part of the forepaw was present in 28 % of all self-mutilating animals after previous nociceptive stimulation. In terms of self-mutilation, these results suggest 1) the crucial role of anesthesia, especially that which involved NMDA receptors (ketamine), and 2) the need of an additional factor to chronic deafferentation, formed either by activity of nociceptive pathways just before rhizotomy (nociceptive stimulation preceding ketamine anesthesia) or by injury discharges (pentobarbital anesthesia).
机译：已知在全身麻醉下进行臂丛神经的单侧背根神经切断术（C5-Th1）可诱导大鼠自残。这项研究的目的是确定不同的麻醉剂和根除术前伤害性刺激对自残现象的影响。在戊巴比妥麻醉下进行根茎切除后，有78％的动物出现了自我变异。当氯胺酮用作全身麻醉剂时，自我毁坏几乎被抑制（13％），并且由表面侵蚀组成。机械伤害感受刺激在氯胺酮麻醉诱导和随后的根茎切开术之前使用时，在91％的大鼠中引起了自残。此外，在先前的伤害性刺激后，所有自残动物中有28％出现了严重的自残类型，包括前肢远端截肢。在自残方面，这些结果表明1）麻醉的关键作用，尤其是涉及NMDA受体（氯胺酮）的麻醉，以及2）慢性脱除咖啡因需要附加的因素，这可能是由于之前的伤害感受途径的活动所形成的。根茎切开术（氯胺酮麻醉前的伤害感受刺激）或损伤放电（戊巴比妥麻醉）。

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