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首页> 外文期刊>Photochemistry and Photobiology: An International Journal >Monitoring microcirculation changes in port wine stains during vascular targeted photodynamic therapy by laser speckle imaging
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Monitoring microcirculation changes in port wine stains during vascular targeted photodynamic therapy by laser speckle imaging

机译：通过激光散斑成像技术监测血管靶向光动力疗法过程中鲜红斑痣的微循环变化

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摘要

This study was conducted to test laser speckle perfusion imaging (LSPI) for imaging microcirculation and monitoring microcirculatory changes of port wine stains (PWS) during vascular targeted photodynamic therapy (V-PDT). Before and 5 min after V-PDT, PWS lesions and the corresponding contralateral healthy skins of 24 PWS patients were scanned, whereas seven PWS patients were scanned throughout V-PDT. V-PDT was conducted immediately after intravenous injection of photocarcinorin (4-5 mg kg ~(-1)). A 532 nm laser was used for irradiation (power density: 80-100 mW cm ~(-2), exposure time: 20-50 min). Before V-PDT, all 24 PWS patients demonstrated a significant difference in perfusion between the PWS lesion and the contralateral healthy control skin (1132 ± 724 and 619 ± 478 PU, respectively, P < 0.01). Five minutes after V-PDT, the mean perfusion value of the 24 PWS lesions was 1246 ± 754 PU. There was no significant difference compared to the perfusion before V-PDT (P > 0.05). During V-PDT, the perfusion of seven PWS patients increased rapidly after initiation of V-PDT, reached a maximum within 10 min, lasted for several minutes, and slowly returned to a relatively lower level at the end of V-PDT. On the basis of these results, LSPI is capable of imaging PWS microvasculature and monitoring microvascular reactivity to V-PDT.
机译：进行这项研究以测试激光散斑灌注成像（LSPI），以对微循环成像并监测血管靶向光动力疗法（V-PDT）期间鲜红斑痣（PWS）的微循环变化。在V-PDT之前和之后5分钟，对24例PWS患者的PWS病变和相应的对侧健康皮肤进行了扫描，而在整个V-PDT中扫描了7例PWS患者。静脉注射光致癌蛋白（4-5 mg kg〜（-1））后立即进行V-PDT。使用532nm激光进行照射（功率密度：80-100mW cm-（-2），曝光时间：20-50min）。在进行V-PDT之前，所有24名PWS患者在PWS病变和对侧健康对照皮肤之间均表现出明显的灌注差异（分别为1132±724和619±478 PU，P <0.01）。 V-PDT后五分钟，24个PWS病变的平均灌注值为1246±754 PU。与V-PDT之前的灌注相比，无显着差异（P> 0.05）。在V-PDT期间，七名PWS患者的灌注在开始V-PDT之后迅速增加，在10分钟内达到最大值，持续了几分钟，并在V-PDT结束时缓慢恢复到相对较低的水平。基于这些结果，LSPI能够对PWS微血管成像并监测微血管对V-PDT的反应性。

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