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Vasopressin V1a and V1b receptors: From molecules to physiological systems

机译：加压素V1a和V1b受体：从分子到生理系统

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The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of physiological functions, including water reabsorption, cardiovascular homeostasis, hormone secretion, and social behavior. These and other actions of AVP are mediated by at least three distinct receptor subtypes: V1a, V1b, and V2. Although the antidiuretic action of AVP and V2 receptor in renal distal tubules and collecting ducts is relatively well understood, recent years have seen an increasing understanding of the physiological roles of V1a and V1b receptors. The V1a receptor is originally found in the vascular smooth muscle and the V1b receptor in the anterior pituitary. Deletion of V1a or V1b receptor genes in mice revealed that the contributions of these receptors extend far beyond cardiovascular or hormone-secreting functions. Together with extensively developed pharmacological tools, genetically altered rodent models have advanced the understanding of a variety of AVP systems. Our report reviews the findings in this important field by covering a wide range of research, from the molecular physiology of V1a and V1b receptors to studies on whole animals, including gene knockout/knockdown studies.
机译：神经垂体激素精氨酸加压素（AVP）对于多种生理功能至关重要，包括水分吸收，心血管稳态，激素分泌和社交行为。 AVP的这些和其他作用由至少三种不同的受体亚型介导：V1a，V1b和V2。尽管AVP和V2受体在肾远端小管和收集管中的抗利尿作用已得到相对较好的了解，但近年来人们对V1a和V1b受体的生理作用有了越来越多的了解。 V1a受体最初存在于血管平滑肌中，而V1b受体存在于垂体前叶中。小鼠中V1a或V1b受体基因的缺失表明，这些受体的作用远远超出了心血管或激素分泌功能。与广泛开发的药理学工具一起，基因改变的啮齿动物模型提高了对各种AVP系统的理解。我们的报告回顾了这一重要领域的发现，涵盖了从V1a和V1b受体的分子生理学到整个动物研究（包括基因敲除/敲除研究）在内的广泛研究。

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