Voltage-gated calcium channels and idiopathic generalized epilepsies.

Khosravani H; Zamponi GW

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Voltage-gated calcium channels and idiopathic generalized epilepsies.

机译：电压门控钙通道和特发性全身性癫痫。

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The idiopathic generalized epilepsies encompass a class of epileptic seizure types that exhibit a polygenic and heritable etiology. Advances in molecular biology and genetics have implicated defects in certain types of voltage-gated calcium channels and their ancillary subunits as important players in this form of epilepsy. Both T-type and P/Q-type channels appear to mediate important contributions to seizure genesis, modulation of network activity, and genetic seizure susceptibility. Here, we provide a comprehensive overview of the roles of these channels and associated subunits in normal and pathological brain activity within the context of idiopathic generalized epilepsy.

机译：特发性全身性癫痫包括一类表现出多基因和遗传病因的癫痫发作类型。分子生物学和遗传学的进展已暗示某些类型的电压门控钙通道及其辅助亚基中的缺陷，是这种癫痫病的重要参与者。 T型和P / Q型通道似乎都对癫痫发作的发生，网络活动的调节和遗传性癫痫易感性起重要作用。在这里，我们提供了在特发性全身性癫痫背景下这些通道和相关亚基在正常和病理性脑活动中的作用的全面概述。

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《Physiological Reviews》 |2006年第3期|共26页
作者
Khosravani H; Zamponi GW;
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正文语种 eng
中图分类基础医学;
关键词
Calcium Channels; Epilepsy; Generalized; 钙通道; 癫痫; 全身型;

机译：Calcium Channels;Epilepsy;Generalized;钙通道;癫痫;全身型;

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1. Voltage-gated calcium channels and idiopathic generalized epilepsies. [J] . Khosravani H, Zamponi GW Physiological Reviews . 2006,第3期

机译：电压门控钙通道和特发性全身性癫痫。
2. Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. [J] . Haug K, Warnstedt M, Alekov AK, Nature Genetics . 2003,第4期

机译：编码电压门控氯通道的CLCN2中的突变与特发性全身性癫痫相关。
3. A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies. [J] . Zhong X, Liu JR, Kyle JW, Human Molecular Genetics . 2006,第9期

机译：CACNA1H的替代RNA剪接和转录变异的概况，CACNA1H是特发性广义癫痫的人类T通道基因候选者。
4. Microstructured Topography Enhanced the Responsiveness of Voltage-gated Calcium Channels in H945RB.3 Human Neural Progenitor Cells [C] . Ze-Zhi Wu, William S.Kisaalita, Lina Wang, The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议）论文集 . 2009

机译：微结构地形增强了H945RB.3人类神经祖细胞中电压门控钙通道的响应能力。
5. Alternative splice sites and transcript variations of CACNA1H---A human T-calcium channel gene candidate for idiopathic generalized epilepsies. [D] . Zhong, Xiaoli. 2008

机译：CACNA1H的其他剪接位点和转录本变异-特发性广义癫痫的人类T钙通道基因候选者。
6. Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. [O] . A Escayg, M De Waard, D D Lee, 2000

机译：特发性全身性癫痫和偶发性共济失调患者中人钙通道β4亚基基因CACNB4的编码和非编码变异。
7. Retraction Note: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies [O] . Karsten Haug, Maike Warnstedt, Alexi K Alekov, 2009

机译：收缩注意：编码电压门控氯通道的CLCN2中的突变与特发性广义癫痫有关

Voltage-gated calcium channels and idiopathic generalized epilepsies.

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