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首页> 美国政府科技报告 >Aerosolized Staphylococcal Enterotoxin B-Induced Pulmonary Lesions in RhesusMonkeys (Macaca mulatta)
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Aerosolized Staphylococcal Enterotoxin B-Induced Pulmonary Lesions in RhesusMonkeys (Macaca mulatta)

机译：雾化金黄色葡萄球菌肠毒素B诱导的猕猴（macaca mulatta）肺部病变

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The pathology of aerosolized staphylococcal enterotoxin B (SEB) was studied inthe nonhuman primate. Six juvenile rhesus monkeys that received multiple lethal inhaled doses of SEB developed diarrhea and vomiting within 24 hours followed by depression, dyspnea and shock. Three of 6 animals died by 52 hours. The most striking gross lesion in all 6 monkeys was diffuse severe pulmonary edema. Histologically, edema fluid was present within the peri-bronchiolar, -broncial and -vascular interstitium, alveolar septa, and alveoli. The adventitia of pulmonary vessels was infiltrated by lymphocytes, macrophages, and fewer neutrophils. Numerous large lymphocytes with occasional mitotic figures were within pulmonary vessels, often occluding alveolar capillaries. These cells were strongly immunoreactive with monoclonal antibodies against cD3, establishing them as T-cells. Ultrastructurally, endothelial cell junctions were intact, and endothelial cells and type I pneumocytes contained numerous pinocytotic vesicles. Alveolar septal interstitial spaces were expanded by edema. The mechanism of these SEB-induced pulmonary lesions was not determined. We hypothesize that cytokine production by activated T-cells may have caused vascular permeability changes leading to widespread pulmonary edema and shock.

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