首页> 美国政府科技报告 >Irradiated Sporozoite Vaccine Induces HLA-B8-Restricted Cytotoxic T LymphocyteResponses against Two Overlapping Epitopes of the Plasmodium falciparum Sporozoite Surface Protein 2

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Irradiated Sporozoite Vaccine Induces HLA-B8-Restricted Cytotoxic T LymphocyteResponses against Two Overlapping Epitopes of the Plasmodium falciparum Sporozoite Surface Protein 2

机译：辐照子孢子疫苗诱导HLa-B8限制性细胞毒性T淋巴细胞对两种重叠的恶性疟原虫子孢子表面蛋白2重叠表位的响应

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Summary Vaccines designed to protect against malaria by inducing CD8+ cytotoxic Ilymphocytes (CIL) in individuals of diverse HLA backgrounds must contain multiple consen'ed epitopes from various preetythrocytic%stage antigens. Plas,nodiu'n fakipan%ni sporozoite surface protein 2 (PfsSP2) is considered an important antigen for inclusion in sud% vaccines, because CD8+ CTL against the P. 1%oe% SSP2 protect mice against malaria by eliminating infected hepatocytes. To develop

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Wizel, B.; Houghten, R. A.; Parker, K. C.; Coligan, J. E.; Gordon, D. M.;
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年度 1995
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总页数 12
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
T lymphocytes; Sporozoites; Plasmodium falciparum; Vaccines; Cells; Peptides; Targets; Irradiation; Mice; Liver; Malaria; Cells(Biology); Nuclei; Blood cells; Lysis; Reprints;

机译：T淋巴细胞;子孢子;恶性疟原虫;疫苗;细胞;肽;靶标;辐射;小鼠;肝脏;疟疾;细胞（生物学）;细胞核;血细胞;裂解;重印;

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1. Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2. [J] . B Wizel, R A Houghten, K C Parker, The Journal of Experomental Medicine . 1995,第5期

机译：辐射的子孢子疫苗诱导针对恶性疟原虫子孢子表面蛋白2的两个重叠表位的HLA-B8限制性细胞毒性T淋巴细胞反应。
2. HLA-A2-restricted cytotoxic T lymphocyte responses to multiple Plasmodium falciparum sporozoite surface protein 2 epitopes in sporozoite-immunized volunteers. [J] . Wizel B, Houghten R, Church P, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1995,第2期

机译：HLA-A2限制了对子孢子免疫志愿者中多个恶性疟原虫子孢子表面蛋白2表位的细胞毒性T淋巴细胞反应。
3. Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes. [J] . Y Charoenvit, V Fallarme, W O Rogers, Infection and immunity . 1997,第8期

机译：两种针对恶性疟原虫子孢子表面蛋白2的单克隆抗体的开发以及B细胞表位的定位。
4. Immunogenicity of Malaria Vaccine Candidate-Plasmodium falciparum Merozoite Surface Protein 5 (PfMSP5) Expressed in Bacillus subtilis [C] . Chittibabu Gottimukkala, Charles Ma, Hans J. Netter International Conference on Chemical, Biological and Environmental Engineering . 2014

机译：疟疾疫苗候选疟原虫的免疫原性是恶魔植物在枯草芽孢杆菌中表达的疟原虫候选疟原虫疟原虫表面蛋白5（PFMSP5）
5. Analysis of Antibody-Induced Plasmodium falciparum Sporozoites Through Scanning Electron Microscopy [D] . Bera, Sagorika D. 2017

机译：通过扫描电子显微镜分析抗体诱导的疟原虫孢子孢子
6. Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2 [O] . 1995

机译：辐射的子孢子疫苗诱导针对恶性疟原虫子孢子表面蛋白2的两个重叠表位的HLA-B8限制性细胞毒性T淋巴细胞应答
7. Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2 [O] . 1995

机译：辐射的子孢子疫苗诱导针对恶性疟原虫子孢子表面蛋白2的两个重叠表位的HLA-B8限制性细胞毒性T淋巴细胞应答
8. Characterization of Plasmodium falciparum Sporozoite Surface Protein 2(malaria/vaccine/thrombospondin related anonymous protein/T-cell Western blot/circumsporozoite protein) [R] . Rogers, W. O., Malik, A., Mellouk, S., 1992

机译：恶性疟原虫子孢子表面蛋白2的表征（疟疾/疫苗/血小板反应蛋白相关的匿名蛋白/ T细胞蛋白质印迹/环子孢子蛋白）

Irradiated Sporozoite Vaccine Induces HLA-B8-Restricted Cytotoxic T LymphocyteResponses against Two Overlapping Epitopes of the Plasmodium falciparum Sporozoite Surface Protein 2

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