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Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Microbial Sources

机译：微生物源生物活性次生代谢产物的分离和结构鉴定

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Microbial organisms often produce biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay-guided fractionations were employed on a variety of natural products sources. Active compounds were characterized by spectroscopic analysis and X-ray diffraction methods. As a result of these studies, six projects were completed, resulting in the purification of a diverse range of compounds containing activity in a variety of assays. A coumarin and parahydroxyphenylethanol were determined to possess phytotoxic activity from fungal pathogens. Two novel C-glycosidic compounds from a bacterial plant pathogen were found to be the first low molecular weight elicitors of the hypersensitive response in plants. A verticillin of the epi- polythiodiketopiperazine class isolated from a soil fungus was discovered to be responsible for inhibition of ras farnesylation transferase. Leafcutter ants were found to be deterred by the presence of a novel sesqualterpenoid in epiphylls. Finally, inhibitors of the PDGF receptor were isolated and characterized from a lichen.

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作者
Graham, K. J.;
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年度 1994
页码 1-125
总页数 125
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
X ray diffraction; Fungi; Metabolites; Microorganisms; Pathogens; Spectroscopy; Molecular weight; Isolation; Purification; Soils; Inhibition; Pathogenic microorganisms; Bioassay; Formicidae; Lichens;

机译：X射线衍射;真菌;代谢物;微生物;病原体;光谱学;分子量;分离;纯化;土壤;抑制;病原微生物;生物测定;蚁科;地衣;

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1. Isolation, purification and structure elucidation of three new bioactive secondary metabolites from Streptomyces lividans AM [J] . MOHAMMAD EL-METWALLY, MAMDOUH ABDEL-MOGIB, MANAL ELFEDAWY, Biocell . 2021,第5期

机译：来自链霉菌的三种新的生物活性次生代谢物的分离，纯化和结构阐明Lividans AM
2. Bioactive secondary metabolites from new terrestrial Streptomyces sp TN82 strain: Isolation, structure elucidation and biological activity [J] . El Euch Imene Zendah, Frese Marcel, Sewald Norbert, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2018,第4期

机译：来自新陆生链霉菌的生物活性次生代谢物SP TN82菌株：分离，结构阐明和生物活性
3. Bioactivity-guided isolation of cytotoxic secondary metabolites from the roots of Glycyrrhiza glabra and elucidation of their mechanisms of action [J] . Cevik Dicle, Yilmazgoz S. Burcin, Kan Yuksel, Industrial Crops and Products . 2018,第期

机译：从甘草毒素根系中的细胞毒性次生代谢物的生物活动引导分离，并阐明了它们的作用机制
4. Studies on endophytic actinomycetes.(1).isolation of actinomycetes from plants and bioactivity of their secondary metabolites [C] . Yukio Sato, Yoshitaka Shibata, Ryuji Yoshida, Asian conference on plant pathology . 2000

机译：内生菌菌的研究。（1）。来自植物和次级代谢产物的植物和生物活性的溶解剂
5. Isolation and structure elucidation of bioactive secondary metabolites from microbial sources. [D] . Graham, Kate Janine. 1994

机译：微生物来源的生物活性次生代谢产物的分离和结构解析。
6. Bioactive metabolites produced by Streptomyces Cheonanensis VUK-A from Coringa mangrove sediments: isolation structure elucidation and bioactivity [O] . Ushakiranmayi Mangamuri, Vijayalakshmi Muvva, Sudhakar Poda, 2016

机译：链霉菌VUK-A从Coringa红树林沉积物中产生的生物活性代谢物：分离结构解析和生物活性
7. Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Four Actinomycetes [O] . 杨晨 2012

机译：四种放线菌的生物活性次生代谢产物的分离和结构解析

Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Microbial Sources

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