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Chemical Interactions of Binary Mixture of Selected Polychlorinated Biphenyls in Rat Hepatoma Cell Line (H4IIE)

机译：大鼠肝癌细胞系（H4IIE）中多氯联苯二元混合物的化学相互作用

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One of the most sensitive biochemical responses to the exposure of 2, 3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) is the induction of ethoxyresorufin-O-deethylase (EROD). To investigate interactions among TCDD and PCBs, rat hepatoma cells (H4IIE) were exposed to the mixtures of 2,4,5,2',4', 5-hexachlorobiphenyl (PCB number 153,fg-microg quantities) and ED50 doses of either TCDD, PCB number 77 (3,4,3,4'-tetrachlorobiphenyl), or PCB number 126 (3, 4,5,3',4'-pentachlorobiphenyl) for 72 hours. EROD activities were measured by spectrofluorometry and dose-related synergistic effects observed in these binary mixtures. At higher concentrations, hover, PCB number 153 was an antagonist to TCDD and PCR number 126.

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作者
Yu, K. ; Tillitt, D. ; Channel, S. ; Burton, A. ; Fisher, J.;
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年度 1993
页码 1-22
总页数 22
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Chemical reactions; Polychlorinated biphenyls; Rats; Spectroscopy; Biochemistry; Enzymes; Neoplasms; Sensitivity; Mixtures; Response; Concentration(Composition); Liver; Fluorometers; Cells(Biology); Chlorinated hydrocarbons; Dioxins;

机译：化学反应;多氯联苯;大鼠;光谱学;生物化学;酶;肿瘤;敏感性;混合物;反应;浓度（组成）;肝;荧光计;细胞（生物学）;氯代烃;二恶英;

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1. Inducing effects of dioxin-like polychlorinated biphenyls on CYP1A in the human hepatoblastoma cell line HepG2, the rat hepatoma cell line H4IIE, and rat primary hepatocytes: comparison of relative potencies. [J] . Zeiger M, Haag R, Hockel J, Toxicological sciences: An official journal of the Society of Toxicology . 2001,第1期

机译：二恶英样多氯联苯对人肝母细胞瘤细胞系HepG2，大鼠肝癌细胞系H4IIE和大鼠原代肝细胞中CYP1A的诱导作用：相对效力的比较。
2. ETHOXYRESORUFIN-O-DEETHYLASE INDUCTION POTENCY OF POLYCHLORINATED DIPHENYL ETHERS IN H4IIE RAT HEPATOMA CELLS [J] . JAANA KOISTINEN, J. THOMAS SANDERSON, JOHN P. GIESY, Environmental toxicology and chemistry . 1996,第11期

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3. Temperature dependence of physical-chemical properties of selected chemicals of environmental interest. II. Chlorobenzenes, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and dibenzofurans [Review] [J] . Shiu WY., Ma KC. Journal of Physical and Chemical Reference Data . 2000,第3期

机译：环境兴趣选择化学品物理化学性质的温度依赖性。 II。氯苯，多氯联苯，聚氯氯二苯苄硫脲 - 二恶英和二苯并呋喃[评论]
4. Interaction in Binary Mixture of Surfactants 3. The Effect of Structure and Temperature on Mixed Micelles [C] . Wang Zhong - ni, Li Gan - zhuo, Wang Yan, International conference on surfactant detergents . 2000

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5. Differential effects of polychlorinated biphenyl (PCB) mixtures and congeners on the disposition of thyroxine (T(4)) in rats. [D] . Martin, Lori Ann. 2002

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6. Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1) [O] . Yungang Liu, Hans-Joachim Lehmler, Larry W. Robertson, -1

机译：羟基化多氯联苯的物理化学性质有助于预测其与大鼠磺基碱1a1相互作用（rsult1a1）
7. Inducing Effects of Dioxin-like Polychlorinated Biphenyls on CYP1A in the Human Hepatoblastoma Cell Line HepG2, the Rat Hepatoma Cell Line H4IIE, and Rat Primary Hepatocytes: Comparison of Relative Potencies [O] . M. Zeiger 2001

机译：二氧化二恶英多氯联苯对Cyp1a对人肝细胞系细胞系Hepg2，大鼠肝癌细胞系H4IIE和大鼠原发性肝细胞的影响：相对型蹄子的比较

Chemical Interactions of Binary Mixture of Selected Polychlorinated Biphenyls in Rat Hepatoma Cell Line (H4IIE)

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