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首页> 美国政府科技报告 >Synthesizing Regularity Exposing Attributes in Large Protein Databases
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Synthesizing Regularity Exposing Attributes in Large Protein Databases

机译：大蛋白质数据库中合成规律性暴露属性

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This thesis describes a system that synthesizes regularity exposing attributesfrom large protein databases. After processing primary and secondary structure data, this system discovers an amino acid representation that captures what are thought to be the three most important amino acid characteristics (size, charge, and hydrophobicity) for tertiary structure prediction. A neural network trained using this 16 bit representation achieves a performance accuracy on the secondary structure prediction problem that is comparable to the one achieved by a neural network trained using the standard 24 bit amino acid representation. In addition, the thesis describes bounds on secondary structure prediction accuracy, derived using an optimal learning algorithm and the probably approximately correct (PAC) model. Representation reformulation, Neural networks, Genetic algorithms, Clustering algorithm, Decision tree system, Secondary structure prediction.

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