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首页> 美国政府科技报告 >Modal Gating of Na+ Channels as a Mechanism of Persistent Na+ Current inPyramidal Neurons from Rat and Cat Sensorimotor Cortex
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Modal Gating of Na+ Channels as a Mechanism of Persistent Na+ Current inPyramidal Neurons from Rat and Cat Sensorimotor Cortex

机译：Na +通道的模式选通作为大鼠和猫感觉运动皮层的锥体神经元持续Na +电流的机制

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The kinetic behavior of brain Na+ channels was studied in pyramidal cells fromrat and cat sensorimotor cortex using either the thin slice preparation or acutely isolated neurons. Single-channel recordings were obtained in the cell-attached and inside-out configuration of the patch-clamp technique. Na+ channels had a conductance of about 16 pS. Patches always contained several Na+ channels, usually 412. In both preparations, long depolarizing pulses revealed two distinct patterns of late Na+ channel activity following transient opening. (1) Na+ channels displayed sporadic brief late openings sometimes clustered to minibursts of 10-40 msec. These events occurred at a low frequency yielding open probability (NP) values below 0.01 (mean = 0.0034). (2) In the second gating mode, an individual Na+ channel in the patch failed to inactivate and produced a burst of openings often lasting to the end of the pulse. This behavior was observed in about 1% of depolarizations.

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