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Assessment of Serological Assays for the Diagnosis of HIV-1 Infections

机译：评估血清学检测诊断HIV-1感染

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Many serologic techniques are available for the detection of HIV-1 infection, buttheir diagnostic performances have been reported to vary depending on the testing situations. We evaluated eight different serologic assays for detecting HIV-1 antibody in sera from suspected high risk groups in North and East Africa. These included : one ELISA bead assay, three indirect ELISAs, two competitive ELISA assays, one gelatin agglutination assay and a recombinant dot-blot assay. A panel of 38 HIV-1 antibody confirmed positive human sera and a panel of 60 HIV negative sera were tested. All sera yielding discordant results were tested for verification of reactivity. Among the different assays evaluated for detecting HIV-1 antibody, sensitivities ranged from 0.919 to 0.974 and test efficiencies

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