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Role of Cytokines (Interleukin 1, Tumor Necrosis Factor, and Transforming GrowthFactor Beta) in Natural and Lipopolysaccharide-Enhanced Radioresistance

机译：细胞因子（白细胞介素1，肿瘤坏死因子和转化生长因子β）在天然和脂多糖增强的放射抗性中的作用

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Studies of radioresistance and radioprotection provide an excellent in vivo modelfor dissection of the pathophysiological role of cytokines. The availability of neutralizing antibodies to cytokines has made it possible to assess the contribution of cytokines to host defense and repair processes involved in radioresistance and radioprotection. Administration of anti-interleukin 1 receptor (IL-1R) antibody (35F5) or anti-tumor necrosis factor (TNF) antibody (TN3 19.12) reduced survival of irradiated CD2F1 mice. These results demonstrate conclusively that natural levels of IL-1 and TNF contribute to radioresistance of normal mice. Furthermore, the radioprotective effect of administered IL-1 was blocked not only with anti-IL-1R antibody but also with anti-TNF antibody. Similarly, the radioprotective effect of TNF was reduced with anti-IL-1R antibody.

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Neta, R.; Oppenheim, J. J.; Schreiber, R. D.; Chizzonite, R.; Ledney, G. D.;
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年度 1991
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总页数 7
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Radioprotective agents; Antibodies; Dissection; Growth(General); In vivo analysis; Models; Necrosis; Neoplasms; Neutralization; Nuclear radiation protection; Reduction; Repair; Survival(General); Reprints;

机译：辐射防护剂;抗体;解剖;生长（一般）;体内分析;模型;坏死;肿瘤;中和;核辐射防护;还原;修复;存活（一般）;重印;

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1. Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide-enhanced radioresistance. [J] . R Neta, J J Oppenheim, R D Schreiber, The Journal of Experomental Medicine . 1991,第5期

机译：细胞因子（白介素1，肿瘤坏死因子和转化生长因子β）在天然和脂多糖增强的放射抗性中的作用。
2. Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. [J] . Smirnova MG, Kiselev SL, Gnuchev NV, European cytokine network . 2002,第2期

机译：促炎性细胞因子肿瘤坏死因子-α，白介素-1β，白介素-6和白介素8在渗出性中耳炎的发病机制中的作用。
3. Role of cytokine gene (interferon-γ, transforming growth factor-β1, tumor necrosis factor-α, interleukin-6, and interleukin-10) polymorphisms in the risk of oral precancerous lesions in Taiwanese [J] . Han-Jen Hsu, Yi-Hsin Yang, Tien-Yu Shieh, Kaohsiung Journal of Medical Sciences . 2014,第11期

机译：细胞因子基因（干扰素-γ，转化生长因子-β1，肿瘤坏死因子-α，白介素-6和白介素-10）多态性在台湾口腔癌前病变风险中的作用
4. Additive Effects of Simvastatin and Ranripril on Inflammatory Cytokines Interferon-y, Tumor Necrosis Factor-a, Interleukin-6 and C-Reactive Protein in Diabetic Patients with Hyperlipidemia and Coronary Artery Disease [C] . L. Tan, S. Tan, L. Berk, International Congress on Coronary Artery Disease . 2003

机译：辛伐他汀和RanRipril对糖尿病患者患者高脂血症和冠状动脉疾病炎症细胞因子干扰素-Y，肿瘤坏死因子-A，白细胞介素-6和C反应蛋白的添加剂效应
5. Effect of the infection with porcine reproductive and respiratory syndrome virus on the regulation of cytokines - tumor necrosis factor-alpha and interleukin-10. [D] . Subramaniam, Sakthivel. 2011

机译：猪繁殖与呼吸综合征病毒感染对细胞因子-肿瘤坏死因子-α和白介素-10调节的影响。
6. Role of cytokines (interleukin 1 tumor necrosis factor and transforming growth factor beta) in natural and lipopolysaccharide- enhanced radioresistance [O] . 1991

机译：细胞因子（白介素1肿瘤坏死因子和转化生长因子β）在天然和脂多糖增强的放射抵抗中的作用
7. Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide- enhanced radioresistance [O] . 1991

机译：细胞因子（白介素1，肿瘤坏死因子和转化生长因子β）在天然和脂多糖增强的放射抵抗中的作用
8. Interleukin-8 Expression in Normal Nasal Epithelium and Its Modulation byInfection with Respiratory Syncytial Virus and Cytokines Tumor Necrosis Factor, Interleukin-1, and Interleukin-6 [R] . Becker, S., Koren, H. S., Henke, D. C. 1993

机译：白细胞介素-8在正常鼻上皮细胞中的表达及其对呼吸道合胞病毒和细胞因子肿瘤坏死因子，白细胞介素-1和白细胞介素-6感染的调节作用

Role of Cytokines (Interleukin 1, Tumor Necrosis Factor, and Transforming GrowthFactor Beta) in Natural and Lipopolysaccharide-Enhanced Radioresistance

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