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1,2-dihydropyrazol-3-ones useful to inhibit release of inflammatory cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), from cells

机译：1,2-二氢吡唑-3-酮可抑制炎性细胞因子白细胞介素1（IL-1）和肿瘤坏死因子（TNF）的释放

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摘要

1,2-dihydropyrazol-3-one compounds of formula (I), enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, which are capable of preventing the extracellular release of inflammatory cytokines are disclosed, wherein: R is an ether or amino unit as defined in the specification; R1 is substituted phenyl; and each R2 and R3 unit is independently selected from the group consisting of: (a) hydrogen; and (b) substituted or unsubstituted C1-C10 hydrocarbyl selected from the group consisting of: (i) C1-C10 linear, branched or cyclic alkyl; (ii) C1-C10 aryl; (iii) C1-C10 heterocyclic; and (iv) C1-C10 heteroaryl.

机译：公开了能够防止炎性细胞因子在细胞外释放的式（I）的1，2-二氢吡唑-3-酮化合物，对映体和非对映体形式及其药学上可接受的盐，其中：R为醚或氨基单元。在规范中定义; R1是取代的苯基;每个R 2和R 3单元独立地选自：（a）氢; （b）选自以下的取代或未取代的C1-C10烃基：（i）C1-C10直链，支链或环状烷基; （ii）C1-C10芳基; （iii）C1-C10杂环; （iv）C1-C10杂芳基。

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公开/公告号NZ534869A

专利类型
公开/公告日2006-09-29

原文格式PDF
申请/专利权人 THE PROCTER & GAMBLE COMPANY;
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申请/专利号NZ20030534869
发明设计人 LAUFERSWEILER MATTHEW JOHN;CRAGO CYNTHIA MONESA;CLARK MICHAEL PHILIP;DJUNG JANE FAR-JINE;DE BISWANATH;NATCHUS MICHAEL GEORGE;
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申请日2003-03-12
分类号A61P29/00;C07D403/04;A61K31/505;
国家 NZ
入库时间 2022-08-21 21:38:04

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